Journals / Journal of Clinical and Experimental Investigations / 2014 / Cilt: 5 - Sayı: 2

Uzun süreli oldukça düşük frekanslı manyetik alanın submandibular ve parotis bezlerinde oluşturduğu oksidatif ve antioksidatif yanıt

Oxidative and antioxidative responses in submandibular and parotid glands of rats exposed to long-term extremely low frequency magnetic field

Pages
219–225
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

However, a decrease observed in CAT levels of parotid gland in both the ELF100 and ELF-500 exposure groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Some epidemiologic and laboratory studies have suggested a possible associations between exposure to extremely low frequency magnetic field (ELF-MF) and cancer.
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Key Findings & Data:The aim of the study was to investigate the possible oxidative damage induced by longterm ELF-MF exposure on submandibular and parotid glands of rats.Methods: Rats in the experimental group were exposed to 100 and 500 µT ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans.
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Conclusion & Impact:However, a decrease observed in CAT levels of parotid gland in both the ELF100 and ELF-500 exposure groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Some epidemiologic and laboratory studies have suggested a possible associations between exposure to extremely low frequency magnetic field (ELF-MF) and cancer. However, it is not known underlying mechanisms of this interaction. The aim of the study was to investigate the possible oxidative damage induced by longterm ELF-MF exposure on submandibular and parotid glands of rats.Methods: Rats in the experimental group were exposed to 100 and 500 µT ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans. The same experimental procedures were applied to the sham group, but the ELF generator was turned off. The levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat submandibular and parotid gland.Results: Although some oxidative and antioxidative parameters of submandibular gland were altered by ELF100 and ELF-500 exposure groups, these changes were not statistically significant (p >0.05). However, a decrease observed in CAT levels of parotid gland in both the ELF100 and ELF-500 exposure groups (p

Özet

Amaç: Bazı epidemiyolojik ve laboratuar çalışmalar oldukça düşük frekanslı manyetik alan ile kanser arasında ilişki olduğunu ileri sürmektedir. Ancak bu etkileşimin altında yatan mekanizma tam olarak bilinmemektedir. Çalışmamızın amacı ratlardaki submandibular ve parotis bezleri üzerindeki uzun süreli oldukça düşük frekanslı manyetik alanın oksidatif ve antioksidatif etkilerini araştırmaktır.Yöntemler: Ratlar; çalışma düzeneği olarak günde 2 saat, yedi gün ve 10 ay boyunca insanlar için güvenli kabul edilen 100 ve 500 µT'lık manyetik alana maruz bırakıldı. Aynı prosedür şham konrol grubuna uygulandı, fakat manyetik alan jeneratörü kapalı tutuldu. Çalışmanın bittiği 10. ay'dan sonra katalaz, malondilaldehit, myeloperoksidaz, total antioksidan kapasite, total oksidan status ve oksidatif stres indeks parametreleri ölçüldü.Bulgular: ELF-100 ve ELF-500 uygulama grubunda bulunan ratların submandibular dokusunun bazı oksidatif ve antioksidatif parametrelerinde değişiklik olmakla birlikte, bu değişiklikler istatistiksel olarak anlamlı değildi (p>0.05). Ancak hem ELF-100 ve hem de ELF-500 uygulama grubunda bulunan ratların parotis bezlerinin katalaz düzeyinde anlamlı azalma gözlendi (p

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Cite This Article

DAŞDAĞ, S., AKDAĞ, M., AKDAĞ, M. Z., EREL, Ö. (2022). Uzun süreli oldukça düşük frekanslı manyetik alanın submandibular ve parotis bezlerinde oluşturduğu oksidatif ve antioksidatif yanıt. Journal of Clinical and Experimental Investigations, Cilt: 5 - Sayı: 2, 219–225. https://ajindex.com/articles/561680

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