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Journals / Journal of Cell and Molecular Biology / 2005 / Cilt: 4 - Sayı: 1

MMP-1 polimorfizminin erken dönem osseointegre implant başarısızlığına etkisi: Pilot çalışma

Effect of MMP-1 polymorphism on early term osseointegrated dental implant failure: A pilot study

Cüneyt KARABUDA
Volkan ARISAN
Tayfun ÖZDEMİR
Pages
53–58
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Within the limited results of this study it may be concluded that MMP-1 gene polyrnorphism may be associated with failure during healing time of Osseointegrated dental implants

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Osseointegrated dental implants are widely used for replacing missing teeth.
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Key Findings & Data:Despite of reported high success rates, failures during healing phase of dental implants are still remarkable.
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Conclusion & Impact:Within the limited results of this study it may be concluded that MMP-1 gene polyrnorphism may be associated with failure during healing time of Osseointegrated dental implants
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Osseointegrated dental implants are widely used for replacing missing teeth. Despite of reported high success rates, failures during healing phase of dental implants are still remarkable. Even under strictly controlled cases, sometimes bone tissue does not attach to titanium implant body or the implant body is lost by acute inflammatory reaction during healing phase. Genetic polymorphism may be a promoting factor for this phenomenon. Intravenous blood samples are taken from 11 patients who lost at least one dental implant during healing phase. Genomic DNA was amplified by polymer chain reaction (PCR) and analyzed by endonucleases. Within the limited results of this study it may be concluded that MMP-1 gene polyrnorphism may be associated with failure during healing time of Osseointegrated dental implants

Özet

Osseointegre diş implantları diş eksikliğini giderilmesinde yaygın olarak kullanılmaktadır. Bildirililen yüksek başarı oranlarına rağmen, iyileşme dönemindeki kayıplar halen sorgulanmaktadır. Sıkı kontrol altındaki vakalarda bile kimi zaman konak kemik dokusu implant yüzeyine yapışmamakta veya akut inflemasyon sonucu implant kaybedilmektedir. Genetik polimorfizmin bunda rolü olabilir. İyileşme döneminde en az 1 implant kaybeden 11 hastadan intavenöz kan örnekleri alınmıştır. Genomik DNA polimeraz zincir reaksiyonu (PCR) ile büyütülmüş ve endonükleaz enzimleri ile analiz edilmiştir. Bu çalışma sınırlarında MMP-1 gen poliformizminin osseointegre diş imlantlarının iyileşme dönemindeki kayıplar ile ilişkili olabileceği düşünülebilir.

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Cite This Article

KARABUDA, C., ARISAN, V., ÖZDEMİR, T. (2022). MMP-1 polimorfizminin erken dönem osseointegre implant başarısızlığına etkisi: Pilot çalışma. Journal of Cell and Molecular Biology, Cilt: 4 - Sayı: 1, 53–58. https://ajindex.com/articles/560678

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