The effect of etodolac on the microvascular patency rates

Abstract

Many investigators have attempted to enhance the patency rate of microvascular arterial anastomosis using pharmacological agents. In twenty male New Zealand white rabbits, femoral artery was transected, crushed or injured or cut and anastomosed. There were ten rabbits in the control group and ten other in the etodolac group. The patency rates were evaluated by the standard "milking test" and blood flow of the vessel at 10 mm, 1 day, and 7 days after the anastomoses. Histopatological examination was performed at the 7th postoperative day after the patency test was performed. The analysis revealed progressive endothelial damage on the arterial intima and focal hemorrhages in arterial media in control group, whereas minimal endothelial damage was seen on intima and focal hemorrhages in media in the etodolac group. Etodolac was found to be effectively decreasing the cellular injury on the vessels.