The aim of this study was to investigate chromosomal abnormalities,fetal loss rates,mosaicism,complications and rates of false positive or negative results in patients who underwent amniocentesis.Included in the study were 125 women with prenatal diagnosis indications at 16-20 weeks of gestation.Cytogenetic investigation produced three abnormal karyotypes,giving a chromosomal abnormality rate of 2.4 percent.No mosaicism,complications related to the procedure or false positive or negative results were observed.The study concluded that amniocentesis is a safe and reliable diagnostic procedure for second-trimester high-risk pregnancies when performed by an experienced team.
📌 3 Key Takeaways
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Objective & Hypothesis:The aim of this study was to investigate chromosomal abnormalities,fetal loss rates,mosaicism,complications and rates of false positive or negative results in patients who underwent amniocentesis.Included in the study were 125 women with prenatal diagnosis indications at 16-20 weeks of gestation.Cytogenetic investigation produced three abnormal karyotypes,giving a chromosomal abnormality rate of 2.4 percent.No mosaicism,complications related to the procedure or false positive or negative results were observed.The study concluded that amniocentesis is a safe and reliable diagnostic procedure for second-trimester high-risk pregnancies when performed by an experienced team.
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Key Findings & Data:The aim of this study was to investigate chromosomal abnormalities,fetal loss rates,mosaicism,complications and rates of false positive or negative results in patients who underwent amniocentesis.Included in the study were 125 women with prenatal diagnosis indications at 16-20 weeks of gestation.Cytogenetic investigation produced three abnormal karyotypes,giving a chromosomal abnormality rate of 2.4 percent.No mosaicism,complications related to the procedure or false positive or negative results were observed.The study concluded that amniocentesis is a safe and reliable diagnostic procedure for second-trimester high-risk pregnancies when performed by an experienced team.
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Conclusion & Impact:The aim of this study was to investigate chromosomal abnormalities,fetal loss rates,mosaicism,complications and rates of false positive or negative results in patients who underwent amniocentesis.Included in the study were 125 women with prenatal diagnosis indications at 16-20 weeks of gestation.Cytogenetic investigation produced three abnormal karyotypes,giving a chromosomal abnormality rate of 2.4 percent.No mosaicism,complications related to the procedure or false positive or negative results were observed.The study concluded that amniocentesis is a safe and reliable diagnostic procedure for second-trimester high-risk pregnancies when performed by an experienced team.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
The aim of this study was to investigate chromosomal abnormalities,fetal loss rates,mosaicism,complications and rates of false positive or negative results in patients who underwent amniocentesis.Included in the study were 125 women with prenatal diagnosis indications at 16-20 weeks of gestation.Cytogenetic investigation produced three abnormal karyotypes,giving a chromosomal abnormality rate of 2.4 percent.No mosaicism,complications related to the procedure or false positive or negative results were observed.The study concluded that amniocentesis is a safe and reliable diagnostic procedure for second-trimester high-risk pregnancies when performed by an experienced team.
Özet
Bu çalışmanın amacı,amniyosentez uygulanan hastalardaki;kromozom anomalileri,fetal kayıp oranları,mozaisizm,işleme bağlı komplikasyonlar ile yalancı pozitif ve yalancı negatif sonuçların incelenmesidir. Çalışmaya,prenatal tanı endikasyonu taşıyan 16-20 haftalık gebe 125 kadın katılmıştır. Sonuçta;kromozomal anomali oranı,3 patolojik karyotip ile %2.4 olarak bulunmuş,mozaik bulguya rastlanmamıştır.Ayrıca işleme bağlı komplikasyon ortaya çıkmamış ve yanlış pozitif veya negatif sonuçlara rastlanmamıştır.Böylece,deneyimli bir ekip tarafından gerçekleştirildiğinde amniyosentezin, yüksek risk taşıyan gebeliklerde rahatlıkla uygulanabilen,güvenilir bir prenatal tanı yöntemi olduğu kanısına varılmıştır.
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Cite This Article
TEKŞEN, F., KOÇ, A. (2022). Ankara Üniversitesi Kadın Hastalıkları ve Doğum Prenatal Tanı Laboratuvarında ilk uygulanan amniyosentez vakaları. Journal of Ankara Medical School, Cilt: 22 - Sayı: 3, 159–161. https://ajindex.com/articles/560031