Journals / Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi / 2012 / Cilt: 9 - Sayı: 36

PREMATURE OVARIAN INSUFFICIENCY

PREMATUR OVER YETERSiZLiGi

Pages
1497–1501
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

IVF with donor oocytes is the only treatment option.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Premature Ovarian Insufficiency POF describes the diminished ovarian functions before the age 40.
📊
Key Findings & Data:Related with the infertility treatments no intervention has been found to improve conception rates.
💡
Conclusion & Impact:IVF with donor oocytes is the only treatment option.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Prematlir over yetersizligi · nfertilite · Premature ovarian insufficiency

Abstract

Premature Ovarian Insufficiency POF describes the diminished ovarian functions before the age 40. Related with the clinics of POF, menopausal symptoms, sub fertility, long term cardiovascular dysfunctions, osteoporosis and psychological problems are mentioned. Among the etiological factors most of them are idiopathic, and the less frequently pronounced items consists of oopherectomy, chemotherapy or radiotherapy, genetic factors, autoimmune adrenal and throid problems and FSH reseptor defects. Related with the infertility treatments no intervention has been found to improve conception rates. IVF with donor oocytes is the only treatment option.

Özet

Prematiir over yetersizligi POY , 40 yaşımdan once, overlerin fonksiyon kapasitesindeki azalmay1 ifade eder. POY ile menapozal semptomlar başlar, subfertilite, uzun donemde ortaya çıkabilecek kardiovaskiiler problemler, osteoporoz riski ve hatta psikolojik sıkıntilar oluşabilecek komplikasyonlar arasmdad1r. Etiyolojik faktörler içinde çogu idiopatik olmakla birlikte, ooferektomi, kemoterapi, radyoterapi, genetik bozukluklar, otoimmiine adrenal ve tiroid hastahklan ve FSH reseptör defektleri sayilabilir. Tedavinin temelinde estrojen ve progesteron içeren kombine preparatlarla hormon replasmam vardır. Spontan gebelik çok az gorülür, infertilite tedavilerinin başarısı yok denecek kadar azdır, çocuk sahibi olma ancak ülkemizde yasal olmayan donor oositli IVF ile mümkündür.

🔖

Cite This Article

DOĞANAY, M., ÖZAKŞIT, G., YILMAZ, S., ERYILMAZ, Ö. G. (2022). PREMATURE OVARIAN INSUFFICIENCY. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, Cilt: 9 - Sayı: 36, 1497–1501. https://ajindex.com/articles/558968

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Nelson LM. Clinical Practice: Primary ovarian insufficiency. N Eng J Med 2009; 360:606–14
  2. Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol 1986; 67:604–6
  3. Liao KL, Wood N, Conway GS. Premature menopause and psychological well-being. J Psycho Obstet Gynaecol 2000; 21:167–74
  4. Munster K, Helm P, Schmidt L. Secondary amenorrhoea: prevalence and medical contact – a cross-sectional study from a Danish county. Br J Obstet Gynaecol 2002; 99:430–3
  5. Bakalov VK, Anasti JN, Calis KA, et al. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. Fertil Steril 2005; 84:958–65
  6. Aittomäki K, Lucena JLD, Pakarinen P, et al. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 1995; 82:959–68
  7. Rajangam S, Nanjappa L. Cytogenetic studies in amenorrhea. Saudi Med J 2007; 28:187-92
  8. Simpson JL. Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes. Ann N Y Acad Sci 2008; 1135:146-54
  9. Massad-Costa AM, da Silva ID, Affonso R, Soares JM, Jr., Nunes MG, de Lima GR, Baracat EC. Gene analysis in patients with premature ovarian failure or gonadal dysgenesis: a preliminary study. Maturitas 2007; 57:399-404
  10. Goswami R, Goswami D, Kabra M, Gupta N, Dubey S, Dadhwal V. Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. Fertil Steril 2003; 80:1052–4
  11. Murray A, Webb J, Grimley S, et al. Studies of FRAXA and FRAXE in women with premeture ovarian failure. J Med Genet 1998;35:637-40
  12. Sherman SL., Premeture ovarian failure in the fragile X syndrome, Am J Med Genet 2000;97:189-94
  13. ACOG committe opinion. No. 338: Screening for fragile X syndrome, Obstet Gyncol 2006;107:1483
  14. Conway GS,Kaltsas G, Patel A, et al. Characterization of idiopathic premature ovaian failure. Fertil Steril 1996;65:337-41
  15. Luborsky J, Llanes B, Davies S, et al. Ovarian autoimmunity:greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population. Clin Immunol 1999;90:368-74
  16. Bakalov VK, Vanderhoof VH, Bondy CA, et al. Adrenal antibodies detect asymotomatic auto-immune adrenal insufficiency in young womwn with spontaneous premature ovarian failure. Hum Reprod 2002; 17:2096-100
  17. Kanis JA, Johnell O, Od