Journals / İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2022 / Cilt: 26 - Sayı: 1

COMPARISON OF OLFACTORY DYSFUNCTION IN COVID 19 AND NONCOVID 19 PATIENTS

COVID 19 VE COVID 19 OLMAYAN HASTALARDA KOKU ALMA DİSFONKSİYONUNUN KARŞILAŞTIRILMASI

Pages
51–58
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Presence of olfactory symptoms may be a prognostic criteria such as comorbidity, age, lymphopenia in the future.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Loss of smell is becoming common symptoms in COVID-19.
📊
Key Findings & Data:This study aims to investigate frequency of hyposmia/anosmia and ageusia in COVID-19 patients and correlation between laboratory and prognostic factors.
💡
Conclusion & Impact:Presence of olfactory symptoms may be a prognostic criteria such as comorbidity, age, lymphopenia in the future.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Loss of smell is becoming common symptoms in COVID-19. This study aims to investigate frequency of hyposmia/anosmia and ageusia in COVID-19 patients and correlation between laboratory and prognostic factors. Material and Methods: A total of 235 patients with Influenza-Like Symptoms were included in the study. PCRconfirmed testing and consistent with COVID-19. We assessed olfaction with subjective Visual Analog Scale (VAS). The sinonasal symptoms were evaluated through the Sino-Nasal Outcome Test-22 (SNOT-22). These patients divided groups as normal olfaction group, smell disorder group. All patients were evaluated with clinical, demographic and laboratory results. Results: COVID-19 was diagnosed by RT-PCR positive in 120 patients (51.1%) and by RT-PCR negative in the 115 patient (49.9%). Patients with olfactory disorder was younger than patients without olfactory disorder patients (p = 0.006). Lymphopenia and comorbid diseases were seen more frequently in patients without olfactory disorder (p=0.02, p=0.023, respectively) The mean of total SNOT-22 scores was significantly higher in loss of smell group than normal olfaction group (p = 0.000). 19 (8.1%) patients had isolated loss of smell. Conclusion: Prevalence of olfactory disorder in COVID-19 patients has become an evidence. Olfactory symptoms may play an important role in early diagnosis of COVID-19 disease. Presence of olfactory symptoms may be a prognostic criteria such as comorbidity, age, lymphopenia in the future.

Özet

Olmayan hastalarda hipozmi/anosmi sıklığını ve laboratuvar ve prognostik faktörler arasındaki ilişkiyi araştırmayı amaçlamaktadır. Gereç ve Yöntem: Çalışmaya gribal semptomları olan toplam 235 hasta dahil edildi. PCR onaylı COVID-19 ve COVID 19 olmayan hastaları karşılaştırdık. Koku alma duyusunu subjektif Görsel Analog Skala (GAS) ile değerlendirdik. Sinonazal semptomlar Sino-Nasal Outcome Test-22 (SNOT-22) ile değerlendirildi. Bu hastalar normal koku alma grubu, koku bozukluğu grubu olarak gruplara ayrıldı. Tüm hastalar klinik, demografik ve laboratuvar sonuçları ile değerlendirildi. Bulgular: RT-PCR pozitif, COVID-19 tanılı 120 hastada (%51,1) ve RT-PCR negatif 115 hasta (%49,9) olarak 2 gruba ayrıldı. Koku alma bozukluğu olan hastalar koku alma bozukluğu olmayan hastalardan daha gençti (p = 0.006). Koku alma bozukluğu olmayan hastalarda lenfopeni ve komorbid hastalıklar daha sık görüldü ( p=0.02, p=0.023, sırasıyla) Koku alma bozukluğu olan grupta toplam SNOT-22 puan ortalaması normal koku duyusu grubuna göre anlamlı olarak yüksekti (p = 0.000). 19 (%8,1) hastada izole koku kaybı vardı. Sonuç: COVID-19 hastalarında koku alma bozukluğunun yaygınlığı bir kanıt haline gelmiştir. Koku semptomları COVID-19 hastalığının erken tanısında önemli bir rol oynayabilir. Olfaktör semptomların varlığı gelecekte komorbidite, yaş, lenfopeni gibi prognostik bir kriter olabilir

🔖

Cite This Article

YILDIRIM, O., TOSUN, S., YILDIRIM, G. A., ERGÜN, U., ARI, A., ÖZKAN, H., AYSEL, A., DALGIC, A. (2022). COMPARISON OF OLFACTORY DYSFUNCTION IN COVID 19 AND NONCOVID 19 PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 26 - Sayı: 1, 51–58. https://ajindex.com/articles/557712

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Guan W, Ni Z, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine 2020; 30;382(18):1708-20
  2. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses 2020; 27;12(4):372
  3. Park SE. Epidemiology, virology, and clinical features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19). Clinical and Experimental Pediatrics 2020; 63(4): 119-24
  4. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Medicine and Infectious Disease 2020; 34: 101623
  5. To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infectious Diseases 2020; 20(5): 565-74
  6. CH Yan, F Faraji, DP Prajapati, Boone CE, DeConde AS. Association of Chemosensory Dysfunction and COVID-19 in Patients Presenting With Influenza-Like Symptoms. International Forum of Allergy and Rhinology 2020; 10(7): 806-13
  7. Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Radiology 2020; 295(3): 715-21
  8. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13): 1239–42
  9. He F, Deng Y, Li W. Coronavirus disease 2019 (COVID-19): what we know? Journal of Medical Virology 2020; 92(7): 719- 25
  10. Cetin AC, Kumus O, Keskinoglu P, Sutay S, Ecevit MC. Turkish Validation of the Sino-Nasal Outcome Test-22. Clinical Otolaryngology 2019; 44(4): 557-64
  11. Kowalski LP, Sanabria A, Ridge JA, Ng WT, de Bree R, Rinaldo A et al. COVID-19 pandemic: effects and evidence-based recommendations for otolaryngology and head and neck surgery practice. Head Neck 2020; 42(6): 1259-67
  12. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eu