AI Summary & Key Takeaways
AI InsightWhen trial groups I and II were compared to the control group liver AST activity was significantly increased (p
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Abstract
Summary: In this study, the effects of low doses 2,4 Dichlophenoxyacetic acid (2,4-D) on the liver and kidney of rats were investigated. For this purpose, two trial groups and one control group were used. The trial groups were given 2,4-D intragastrically (l.G) at doses of 25 mg/kg and 40 mg/kg at very other day for a duration of three weeks. At the end of this period, the enzymatic activity of Alanintranzaminase (ALT), Aspartattransaminse (AST) and Gama glutamyltransferase (GGT), in the kidney and liver tissue of the rats were determined. The total protein and the triglis-eride level were determined. Heart, liver and kidney tisues were histopathologically evaluated. When trial groups I and II were compared to the control group liver AST activity was significantly increased (p
Özet
Bu çalışmada, 2,4 Dichlorophenoxyaceticacid (2,4-D)'in düşük dozlarının rat karaciğer ve böbrek dokusu üzerine etkileri incelenmiştir. Bu amaçla ikisi deneme biri kontrol grubu olmak üzere üç grup kullanılmıştır. Deneme gruplarına 2,4-D, 25 mg/kg ve 40 mg/kg dozunda intra gastrik (I.G) yolla 3 hafta süreyle gün aşırı verilmiştir. Deneme sonunda ratlardan alınan karaciğer ve böbrek dokusunda Alanintransaminaz (ALT), Aspartattransaminaz (AST), Gamma-glutamil transpeptidaz (GGT) enzim aktiviteleri, ve total protein, trigliserid düzeyleri saptanmış kalp, karaciğer, böbrek dokularının histopatolojik incelemeleri yapılmıştır. Kontrol grubu ile deneme grupları karşılaştırıldığında, her iki gruba ait karaciğer AST aktivitesinde anlamlı (p