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Journals / İstanbul Üniversitesi Veteriner Fakültesi Dergisi / 2013 / Cilt: 39 - Sayı: 2

Tavuklarda Bisfenol A ve dietilstilbestrol'ün Bursa Fabricius'un involusyonu üzerine etkisi

Effects of Bisphenol A and diethylstilbestrol on the involution of Bursa of Fabricius in the Hens

Abit AKTAŞ
Funda YİĞİT
Suzan DAĞLIOĞLU
Pages
168–174
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In high dose BPA (134 μg/g egg) and DES (0.2 μg/g egg) groups, the bursa somatic index, the number and diameter of the follicles in bursa of Fabricius were statistically decreased compared to control and low dose BPA (67 μg/g egg) and DES (0.02 μg/g egg) groups (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The bursa of Fabricius is a primary ly mphoid organ in birds responsible for B lymphocyte maturation.
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Key Findings & Data:Sex steroid hormones influence regression of the bursa of Fabricius.
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Conclusion & Impact:In high dose BPA (134 μg/g egg) and DES (0.2 μg/g egg) groups, the bursa somatic index, the number and diameter of the follicles in bursa of Fabricius were statistically decreased compared to control and low dose BPA (67 μg/g egg) and DES (0.02 μg/g egg) groups (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The bursa of Fabricius is a primary ly mphoid organ in birds responsible for B lymphocyte maturation. Sex steroid hormones influence regression of the bursa of Fabricius. Bisphenol A (BPA) is an estrogenic chemical that is widely used in the manufacture of plastics and epoxy resins. This experiment was conducted to determine the effects of BPA on the involution of bursa of Fabricius in the adult hens. The synthetic estrogen diethylstilbestrol (DES) was used as a positive control. The test compounds were injected into the yolk of embryonated eggs. Immunohistochemical procedure performed to determine estrogen receptor alpha (ERα) expression in bursa of Fabricius. In high dose BPA (134 μg/g egg) and DES (0.2 μg/g egg) groups, the bursa somatic index, the number and diameter of the follicles in bursa of Fabricius were statistically decreased compared to control and low dose BPA (67 μg/g egg) and DES (0.02 μg/g egg) groups (P

Özet

Bursa Fabricius kuşlarda B lenfositlerin olgunlaşmasından sorumlu primer (birincil) lenfoid organdır. Seks steroid hormonları bursa Fabriciusun gerilemesini etkiler. Bisfenol A (BPA), plastik ve epoksi reçine üretiminde yaygın olarak kullanılan bir östrojenik bir kimyasaldır. Bu çalışma, BPAnın ergin tavuklarda bursa Fabriciusun involusyonu üzerine etkisini belirlemek amacıyla yapıldı. Pozitif kontrol olarak sentetik östrojen olan dietilstilbestrol (DES) kullanıldı. Test bileşikleri embriyolu yumurta sarısının içine enjekte edildi. Bursa Fabriciusda östrojen alfa reseptörü (ÖRα) ekspresyonunu belirlemek için immunohistokimyasal yöntem kullanıldı. Yüksek doz BPA (134 mg/g yumurta) ve DES (0,2 mg/g yumurta) gruplarında, bursa somatik indeks, bursa Fabriciusun follikül sayısı ve çapı, kontrol ve düşük doz BPA (67 μg/g yumurta) ve DES (0,02 μg/g/ yumurta) gruplarına göre istatistiksel olarak azalmıştı (P

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Cite This Article

AKTAŞ, A., YİĞİT, F., DAĞLIOĞLU, S. (2022). Tavuklarda Bisfenol A ve dietilstilbestrol'ün Bursa Fabricius'un involusyonu üzerine etkisi. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 39 - Sayı: 2, 168–174. https://ajindex.com/articles/555174

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References (10)

  1. Al-Afaleq, A.I., Homeida, A.M., 1998. Effects of low doses of oestradiol, testosterone, and dihydrotestosterone on the immune response of broiler chicks. Immunopharmacology and Immunotoxicology 20, 315-327.
  2. Ansar, A.S., 2000. The immune system as a potential target for environmental estrogens (endocrine disrupters): A new emerging field. Toxicology 150 (1-3), 191-206.
  3. Bacha, W.J., Bacha, L.M., 2006. Color atlas of veterinary histology. 2nd edition. Blackwell Publishing Ltd, USA. Berg, C., Halldin, K., Brunstrom, B., 2001. Effects of bisphenol A and tetrabromobisphenol A on sex organ development in quail and chicken embryos. Environmental Toxicology 20, 2826- 2840. Colborn, T., Saal, F.S., Soto, A.M., 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environmental Health Perspectives 101, 378- 384. Crossmon, G., 1937. A modification of Mallory’s connective tissue stain with a discussion of the principles involved. The Anatomical Record 69, 33-38.
  4. Dongmei, L., Ruiping, S., Junzhen, J.I.A., Lili, C., Jiande, W., Tianlong, L., Yanxin, H., Qiong, W., 2008. Effect of bisphenol-a on histomorphology of central immune organ of chick embryos. Science Technology Review 26 (6), 42-49.
  5. Fairbrother, A., Smits, J., Grasman, K.A., 2004. Avian immunotoxicology. Journal of Toxicology and Environmental Health B 7, 105-137.
  6. Fry, D.M., 1995. Reproductive effects in birds exposed to pesticides and industrial chemicals. Environmental Health Perspectives 103, 165- 171. Furuya, M., Adachi, K., Kuwahara, S., Ogawa, K., Tsukamoto, Y., 2006. Inhibition of male chick phenotypes and spermatogenesis by Bisphenol- A. Life Sciences 78, 1767-1776.
  7. Gildersleeve, R.P., Tilson, H.A., Mitchell, C.L., 1985. Injection of diethylstilbestrol on the first day of incubation affects morphology of sex glands and reproductive behavior of Japanese quail. Teratology 131 (1), 101-109.
  8. Glick, B., Chang, T.S., Jaap, R.G., 1956. The bursa of Fabricius and antibody production. Poultry Science 35, 224-225.
  9. Gülmez, N., Aslan, Ş., 1999. Histological and histometrical investigations on bursa of Fabricius and Thymus of Native Geese. Turkish Journal of Veterinary and Animal Science 23 (2), 163-171.
  10. Halldin, K., Berg, C., Bergman, A., Brandt, I., Brunström, B., 2001. Distribution of bisphenol A and tetrabromobisphenol A in quail eggs, embryos and laying birds and studies on reproduction variables in adults following in ovo exposure. Archives of Toxicology 75 (10), 597-603. Kondo,