Journals / İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi / 2014 / Cilt: 48 - Sayı: 3

Obezite ve periodontitis arasındaki karşılıklı ilişki

The two-way relatıonshıp between obesıty and perıodontıtıs

Pages
75–81
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, periodontitis and obesity are diseases that are associated through various cytokines, proteins, vitamins, etc.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Periodontitis and obesity are two chronic inflammatory diseases.
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Key Findings & Data:TNF-alfa and IL-6 are cytokines that are involved in the pathophysiology of both obesity and periodontitis.
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Conclusion & Impact:In conclusion, periodontitis and obesity are diseases that are associated through various cytokines, proteins, vitamins, etc.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Periodontitis and obesity are two chronic inflammatory diseases. Since obesity and periodontitis are associated with systemic inflammation, these two situations are linked by common pathophysiol- ogy. TNF-alfa and IL-6 are cytokines that are involved in the pathophysiology of both obesity and periodontitis. The levels of these cytokines increase with obestiy and periodontitis. Resistin is pro- duced by immune cells and therefore, is related to the activation of inflammatory processes. Increased resistin serum levels have been associated with periodontitis. Adipose tissues also secrete some anti- inflammatory factors, such as adiponectin. Plasma levels of adiponectin are decreased in individuals who are obese, compared with persons who are normal weight. Furthermore, evidence suggests a trend toward decreased adiponectin serum levels and reduced adiponectin function in individuals with periodontitis. In conclusion, periodontitis and obesity are diseases that are associated through various cytokines, proteins, vitamins, etc.

Özet

Periodontitis ve obezite iki kronik enflamatuar hastalıktır. Obezite ve periodontitis sistemik enfla- masyonla ilgili olduklarından bu iki hastalığın ortak patofizyolojiye sahip olduğu söylenebilir. TNF-alfa ve IL-6 obezite ve periodontitisin patofizyolojisinde yer alan sitokinlerdir. Bu sitokinlerin seviyeleri obezite ve periodontitis ile birlikte artar. Resistin immun hücreler tarafından üretilir ve bu yüzden de enflamatuar sürecin aktivasyonunda yer alır. Resistinin pro-enflamatuar özellikleri TNF-alfa ve IL-6 salınımı ve adiponektinin anti-enflamatuar etkilerinin bozulmasıdır. Periodontitiste serumda resistin seviyesi artmaktadır. Aynı zamanda adipoz dokular da adiponektin gibi bazı anti-enflamatuar faktörleri salgılamaktadır. Obez bireylerde normal ağırlıktaki bireylere göre plazmada azalmış adiponektin sevi- yeleri görülmektedir. Ayrıca bilimsel kanıtlar periodontitisli bireylerde serum adiponektin seviyesinin ve fonksiyonunun azaldığını göstermektedir. Sonuç olarak, periodontitis ve obezite çeşitli sitokinler, proteinler, ve vitaminler aracılığıyla birbirleri ile ilişkili iki hastalıktır.

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Cite This Article

ÇİFCİBAŞI, E., ÇİNTAN, S., KARABEY, V. (2022). Obezite ve periodontitis arasındaki karşılıklı ilişki. İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi, Cilt: 48 - Sayı: 3, 75–81. https://ajindex.com/articles/552809

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