Journals / İstanbul Tıp Dergisi / 2010 / Cilt: 11 - Sayı: 4

Laksatif kötüye kullanımı Melanozis koli’ye yol açabilir mi? Olgu sunumu

Melanosis coli, a consequence of laxative abuse? A case report

Pages
171–174
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Melanosis coli is a benign and generally reversible pathology when laxatives are discontinued but may be related to an increased risk of colorectal carcinoma, which should always be kept in mind.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Long-term use of anthraquinone-containing laxatives frequently causes melanosis coli.
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Key Findings & Data:A 27-year-old Turkish woman was being prepared for a hemorrhoidal operation.
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Conclusion & Impact:Melanosis coli is a benign and generally reversible pathology when laxatives are discontinued but may be related to an increased risk of colorectal carcinoma, which should always be kept in mind.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Long-term use of anthraquinone-containing laxatives frequently causes melanosis coli. Our aim was to overview the topic and related literature by presenting the case report of a patient with melanosis coli. A 27-year-old Turkish woman was being prepared for a hemorrhoidal operation. She had a history of chronic constipation and had been using an anthraquinone-containing laxative for the last five years. When colonoscopy was performed, the whole mucosa from the rectum to the cecum was found hyperemic-edematous with brown pigmented areas and some ulcerated-polypoid lesions. Histopathological examination of the colon biopsies revealed melanosis coli. The patient was advised to stop taking the laxative and dietary modifications were made for constipation. Melanosis coli is a benign and generally reversible pathology when laxatives are discontinued but may be related to an increased risk of colorectal carcinoma, which should always be kept in mind.

Özet

Antrakinon içeren laksatiflerin uzun süreli kullanımı, sıklıkla melanozis koliye sebep olur. Amacımız, melanozis koli tanılı bir hastayı sunarak konuyu ve ilgili literatürü gözden geçirmektir. Hasta, hemoroid ameliyatına hazırlanan, 27 yaşındaki bir Türk kadını idi. Hikayesinde kronik kabızlık olup, son 5 yıldır antrakinon içeren bir laksatif çeşidi kullanmakta idi. Hastaya kolonoskopi yapılınca, rektumdan çekuma dek tüm mukozanın yer yer kahverengi lekeli, hiperemik-ödemli olduğu ve bunlara az sayıda ülsere polipoid lezyonun eşlik ettiği görüldü. Kolon biyopsilerinin histopatolojik inceleme sonucu, melanozis koli tanısı ile uyumluydu. Hastaya artık laksatif kullanmaması tavsiye edilerek kabızlık için gerekli beslenme düzenlemeleri yapıldı. Melanozis koli genellikle selim ve laksatifler kesildiğinde geri dönüşümlü bir patolojik durum olmakla birlikte, artmış bir kolorektal karsinom riskinin eşlik edebileceği daima akılda bulundurulmalıdır.

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Cite This Article

TOROS, A. B., ÖZEL, L., ÖZKARA, S., GÜNEŞ, P., ERSÖZ, F. (2022). Laksatif kötüye kullanımı Melanozis koli’ye yol açabilir mi? Olgu sunumu. İstanbul Tıp Dergisi, Cilt: 11 - Sayı: 4, 171–174. https://ajindex.com/articles/552590

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