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Journals / İstanbul Tıp Dergisi / 2011 / Cilt: 12 - Sayı: 3

Gastroenteropankreatik nöroendokrin tümörlerin Ki 67, p16 ve siklin D1 ekspresyonu açısından değerlendirilmesi

Evaluation of gastroenteropancreatic neuroendocrine tumors for Ki 67, p16 and cyclin D1 expression

Esra PAŞAOĞLU
Feray GÜNVER
Erol Rüştü BOZKURT
Gülzade ÖZYALVAÇLI
Zuhal GÜCİN
Kemal BEHZATOĞLU
Pages
105–112
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More objective results can be obtained in such studies that include retinoblastoma protein and analyze all of the components of the Rb pathway.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to examine the roles of p16/cyclin D1 and Ki 67 proliferation index in gastroenteropancreatic neuroendocrine tumors (GEPNETs), which were classified by the World Health Organization (WHO).
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Key Findings & Data:Methods: A series of 41 cases of GEPNETs including 16 well-differentiated endocrine tumors (WDET), 17 welldifferentiated endocrine carcinomas (WDEC) and 8 poorly differentiated endocrine carcinomas (PDEC) were searched for p16, cyclin D1 and Ki 67 expression.
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Conclusion & Impact:More objective results can be obtained in such studies that include retinoblastoma protein and analyze all of the components of the Rb pathway.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to examine the roles of p16/cyclin D1 and Ki 67 proliferation index in gastroenteropancreatic neuroendocrine tumors (GEPNETs), which were classified by the World Health Organization (WHO). Methods: A series of 41 cases of GEPNETs including 16 well-differentiated endocrine tumors (WDET), 17 welldifferentiated endocrine carcinomas (WDEC) and 8 poorly differentiated endocrine carcinomas (PDEC) were searched for p16, cyclin D1 and Ki 67 expression. Results: Overexpression of p16 and cyclin D1 was observed in 8 (50%) and 8 (50%) of 16 WDET cases, 12 (70%) and 5 (29%) of 17 WDEC cases and 5 (63%) and 5 (63%) of 8 PDEC cases. Low Ki 67 index (≤2%) was found in 15 (94%) of WDETs, 13 (76%) of WDECs and none of PDECs. Conclusion: Ki 67 index was low in WDECs as in WDETs. High Ki 67 index (>10%) is related to poor prognosis, but low proliferation activity is not an indicator of benign behavior. There were no significant differences between the tumor groups with respect to p16 and cyclin D1 expression in our study. More objective results can be obtained in such studies that include retinoblastoma protein and analyze all of the components of the Rb pathway.

Özet

Amaç: Bu çalışmanın amacı, Dünya Sağlık Örgütü’ne göre sınıflandırılmış gastroenteropankreatik nöroendokrin tümörlerde (GEPNET) p16 ve siklin D1’in rolünü ve Ki 67 proliferasyon indeksini incelemektir. Gereç ve Yöntem: Toplam 41 olguluk GEPNET serisinin 16’sı iyi diferansiye nöroendokrin tümörden (İDNET), 17’si iyi diferansiye nöroendokrin karsinomdan (İDNEK) ve 8’i az diferansiye nöroendokrin karsinomdan (ADNEK) oluşmaktaydı. Bu tümör grupları p16, siklin D1 ve Ki 67 ekspresyonu açısından incelendi. Bulgular: p16 ve siklin D1 over ekspresyonu İDNET grubunun 8’inde (%50) ve 8’inde (%50), İDNEK grubunun 12’sinde (%70) ve 5’inde (%29), ADNEK grubunun 5’inde (%63) ve 5’inde (%63) izlendi. Düşük Ki 67 indeksi (≤ %2) İDNET grubunun 15’inde (%94), İDNEK grubunun 13’ünde (%76) mevcuttu. Sonuç: Bu çalışmada Ki 67 indeksi, İDNEK grubunda benign gruptaki gibi düşük bulunmuştur. Yüksek Ki 67 indeksi kötü prognoz ile ilişkilidir, ancak proliferatif aktivitenin düşük olması benign davranışın göstergesi olarak değerlendirilmemelidir. Çalışmamızda p16 ve siklin D1 ile ilgili anlamlı bir sonuç elde edilmemekle birlikte daha çok olgudan oluşan, retinoblastom (Rb) proteinin de dahil edildiği ve p16/siklin D1/Rb yolağının tümüyle incelendiği çalışmalarda daha anlamlı sonuçlar elde edilebilir.

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Cite This Article

PAŞAOĞLU, E., GÜNVER, F., BOZKURT, E. R., ÖZYALVAÇLI, G., GÜCİN, Z., BEHZATOĞLU, K. (2022). Gastroenteropankreatik nöroendokrin tümörlerin Ki 67, p16 ve siklin D1 ekspresyonu açısından değerlendirilmesi. İstanbul Tıp Dergisi, Cilt: 12 - Sayı: 3, 105–112. https://ajindex.com/articles/552569

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