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Journals / İstanbul Medical Journal / 2014 / Cilt: 15 - Sayı: 4

Evaluation of the Association of Histopathological Results of Endometrial Biopsies with Body Mass Index and Serum Leptin Levels in Patients with Postmenopausal Bleeding

Postmenopozal Kanamalı Hastalarda Histopatolojik Sonuçların Vücut Kitle İndeksleri ve Serum Leptin Düzeyleri ile İlişkisinin Değerlendirilmesi

Ahmet Birtan BORAN
Güler ATAŞER
Mehmet Aytaç YÜKSEL
İlkbal YÜKSEL TEMEL
Çiğdem YURTSEVER YAVUZCAN
Pelin KOCA
Pages
31–33
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Serum leptin levels in patients with endometrial cancer and hy- perplasia were 32.8 ng/mL as opposed to 20.3 ng/mL in patients with nor- mal endometrial pathology (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To determine whether body mass index (BMI) and serum leptin levels in patients with endometrial hyperplasia and cancer deviate from the values in patients with a normal endometrium.
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Key Findings & Data:Methods: From June 2008 to December 2009, among the patients adminis- tered to our clinic for abnormal uterine bleeding, 86 were included in this study to evaluate the association of histopathological results of endometrial biopsies with BMI and leptin levels.
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Conclusion & Impact:Results: Serum leptin levels in patients with endometrial cancer and hy- perplasia were 32.8 ng/mL as opposed to 20.3 ng/mL in patients with nor- mal endometrial pathology (p
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To determine whether body mass index (BMI) and serum leptin levels in patients with endometrial hyperplasia and cancer deviate from the values in patients with a normal endometrium. Methods: From June 2008 to December 2009, among the patients adminis- tered to our clinic for abnormal uterine bleeding, 86 were included in this study to evaluate the association of histopathological results of endometrial biopsies with BMI and leptin levels. Three groups were formed according to BMI: group I, BMI40. Leptin levels were measured using an immunoenzymatic test. Results: Serum leptin levels in patients with endometrial cancer and hy- perplasia were 32.8 ng/mL as opposed to 20.3 ng/mL in patients with nor- mal endometrial pathology (p

Özet

Amaç: Endometriyal hiperplazili, kanserli hastalar ve normal endometriyumasahip hastalar arasında leptin serum konsantrasyonu ile vücut kitleindeksi ilişkisini belirlenmesi için yaptık.Yöntemler: Haziran 2008 ve Aralık 2009 ayları arasında postmenopozalkanama şikayeti ile kliniğimize başvuran hastaların yapılan endometriyalbiyopsilerinin histopatolojik sonuçlarının, hastaların vücut kitle indeksi veserum Leptin seviyeleri ile karşılaştırılması için 86 hasta seçildi. Vücut kitleindeksine göre üç alt grup kuruldu; grup I40.Leptin düzeyleri immünoenzimatik test kitleri ile ölçüldü.Bulgular: Endometriyal kanserli hastalarda ortalama serum leptinin konsantrasyonu;32,8 ng/mL, normal endometriyuma sahip hastaların ortalamaserum leptinin konsantrasyonu; 20,3 ng/mL bulunmuştur (p

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Cite This Article

BORAN, A. B., ATAŞER, G., YÜKSEL, M. A., TEMEL, İ. Y., YAVUZCAN, Ç. Y., KOCA, P. (2022). Evaluation of the Association of Histopathological Results of Endometrial Biopsies with Body Mass Index and Serum Leptin Levels in Patients with Postmenopausal Bleeding. İstanbul Medical Journal, Cilt: 15 - Sayı: 4, 31–33. https://ajindex.com/articles/552200

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References (7)

  1. Rodger FE, Walker J, Critchley HOD: Investigating the woman with postmenopausal bleeding. TrendsIn UGSH 2005; 10: 1-4
  2. Savelli L, De Iaco P, Santini D, Rosati F, Ghi T, Pignotti E, Bovicelli L. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometriyalpolyps. Am J Obstet Gynecol 2003; 188: 927-31. [CrossRef] 3. Brabant G, Nave H, Mayr B, Behrend M, van Harmelen V, Arner P. Secretion of freeand protein-bound leptin from subcutaneous adipose tissue of lean and obese women. J Clin Endocrinol Metab 2002; 87: 3966-70. [CrossRef] 4. Oriel KA, Schrager S: Abnormal uterine bleeding. American Family Physician 1999; 60: 1371-82
  3. Lurain JR: Uterus Kanseri. In: Berek JS, (ed.) Novak Jinekoloji, Onüçüncü baskı, Nobel Tıp Kitabevleri, İstanbul, 2004, 1143-97
  4. Atasü T, Şahmay S: Uterusunmalign hastalıkları. Jinekoloji, ikinci baskı, Nobel tıp kitabevleri, İstanbul, 2001, 299-322
  5. Agorastos T, Vaitsi V, Pantazis K, Efstathiadis E, Vavilis D, Bontis JN. Aromatase inhibitör anastrozole for treating endometrial hyperplasia in obese postmenopausal women. Eur J Obstet Gynecol Reprod Biol 2005; 118: 239-40. [CrossRef] 8. Kösebay D, Arvas M. EndometriyumKarsinomu. In: Atasü T, Aydınlı K, (eds.) Jinekolojik Onkoloji, ikinci baskı, Logos Yayıncılık, İstanbul, 1999, 346-65
  6. Creasman WT: MalignantTumors of theUterineCorpus. In: Rock JA, Jones HW III, (eds.) Te Linde's Operative Gynecology, ninthedition, Lippincott Williams&Wilkins, Philadelphia, 2003, 1445-86
  7. Vuento MH, Pirhonen JP, Maekinen JI, Tyrkkö JE, Laippala PJ, Grönroos M, et al: Screening for end ometriyal cancer in asymptomatic postmenopausal women with conventional and colour Doppler sonography. Br J Obstet Gynaecol 1999; 106: 14-20. [CrossRef] 11. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of theobese gene product on body weightregulation in ob/obmice. Science 1995; 28: 540-3. [CrossRef] 12. Fistonic I, Hodek B, Klaric P, Jokanovic L, Grubisic G, Ivicevic-Bakulic T. Transvaginal sonographic assessment of premalignant and malignant changes in the endometriyum in postmenopausal bleeding. J Clin Ultrasound 1997; 25: 431-5. [CrossRef] 13. Phillip H, Dacosta V, Fletcher H, Kulkarni S, Reid M. Correlation between transvaginal ultrasound measured endometrial thickness and histopathological findings in Afro-Caribbean Jamaican women with postmenopausal bleeding. J Obstet Gynaecol 2004; 24: 568-72. [CrossRef] 14. Weber AM, Belinson