Journals / İstanbul Medical Journal / 2016 / Cilt: 17 - Sayı: 4

Normotansif Obez Kadınlarda Sol Ventrikül Kitlesinin VKİ ve İnsülin Direnci ile İlişkisi

Relationship of Left Ventricular Mass with BMI and Insulin Resistance in Normotensive Obese Women

Pages
113–117
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Age, insulin value, and BMI were determinants of LVMI (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Obesity is correlated with left ventricular mass (LVM) and insulin resistance (IR) and is an independent predictor of LVM in nondiabetic, non-hypertensive, obese people.
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Key Findings & Data:Methods: 81 obese, normotensive, nondiabetic women and 36 healthy women of normal weight were included in the study.
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Conclusion & Impact:Age, insulin value, and BMI were determinants of LVMI (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Obesity is correlated with left ventricular mass (LVM) and insulin resistance (IR) and is an independent predictor of LVM in nondiabetic, non-hypertensive, obese people. Our aim was to investigate the relationship of body mass index (BMI) and IR with left venticular mass index (LVMI) in obese and nonobese, normotensive, nondiabetic women. Methods: 81 obese, normotensive, nondiabetic women and 36 healthy women of normal weight were included in the study. We compared the demographic features, biochemical values, insulin and HOMA-IR values, heart rate, blood pressure, and echocardiographic parameters of the obese and nonobese subjects.Results: The mean age was 39.3±11.2 years and the mean BMI was 39.5±5.7 kg/m2 in the obese group; the mean age was 38.4±9.5 years and the mean BMI was 22.5±1.9 kg/m2 in the control group. Hyperinsulinemia (19.3±10.4 µU/mL) and IR (HOMA-IR: 4.6±2.9) were correlated with obesity. Insulin levels and IR were associated with LWM, LWMI, aortic diameter (AD), left atrial diameter (LAD), interventricular wall thickness (IVWT), left ventricular end diastolic diameter (IVEDD), and left ventricular posterior wall thickness (LVPWT). Age, insulin value, and BMI were determinants of LVMI (p

Özet

Amaç: Obeziteyle sol ventrikül kütlesi (SVK) arasında korelasyon bulunmuştur. Ayrıca insülin direnci, diyabetli olmayan normotansif obez kişilerde SVK'nin bağımsız bir öngördürücüsüdür. Çalışmamızın amacı normotansif, nondiyabetik obez ve obez olmayan sağlıklı kadınlarda vücut kitle indeksi (VKİ) ve insülin direncinin sol ventrikül hipertrofisinin göstergesi olan sol ventrikül kitle indeksi (SVKİ) ile ilişkisini değerlendirmektir.Yöntemler: Çalışmamızda non diabetik, nonhipertansif 81 obez ve36 kontrol vakasının yaş, boy, kilo, bel çevresi, kan glukoz, üre, kreatinin, albumin, total-kolesterol, LDL-kolesterol, HDL-kolesterol, trigliserid, insulin ve HOMA-IR düzeyleri, kalp hızı, sistolik, diyastolik kan basıncı ölçümleri ve ekokardiyografi parametreleri karşılaştırıldı.Bulgular: Obezlerin yaş ortalamaları 39,3±11,2 yıl ve VKİ: 39,5±5,7 kg/m2, kontrol grubunun ise 38,4±9,5 yıl, VKİ: 22,5±1,9 kg/m2 idi. Beklenildiği üzere obeziteyle insülin düzeyi ve insülin direnci koreleydi. Çalışma grubunda hiperinsülinemi (insülin düzeyi: 19,3±10,4 µU/mL) ve insülin direnci (HOMAIR: 4,6±2,9) saptandı. HOMA-IR ve insülin düzeyinin sol ventrikül kitlesi, sol ventrikül kitle indeksi, aort çapı, sol atrium çapı, interventriküler duvar kalınlığı, sol ventrikül diyastol sonu çapı, sol ventrikül arka duvar kalınlığı (SVK, SVKİ, AÇ, SAÇ, İVDK, SVDSÇ, SVADK ) ile korelasyonu pozitifti. SVKİ'yı belirleyen faktörlerin regresyon analizinde yaş, serum insülin düzeyi ve VKİ anlamlıydı (yaş ve VKİ için p

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Cite This Article

ŞAK, D., ALTUNOĞLU, E., ERDENEN, F., AKBAŞ, F., ALTINOK, R., KANTARCI, F. E. N., KARABAĞ, T. (2022). Normotansif Obez Kadınlarda Sol Ventrikül Kitlesinin VKİ ve İnsülin Direnci ile İlişkisi. İstanbul Medical Journal, Cilt: 17 - Sayı: 4, 113–117. https://ajindex.com/articles/552115

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References (2)

  1. Batalli-Këpuska A, Bajraktari G, Zejnullahu M, Azemi M, Shala M, Batalli A, et al. Abnormal systolic and diastolic myocardial function in obese asymptomatic adolescents. Int J Cardiol, 2013; 168: 2347-51. [CrossRef] Shah RV, Abbasi SA, Neilan TG, Hulten E, Coelho-Filho O, Hoppin A, et al. Myocardial tissue remodeling in adolescent obesity. J Am Heart Assoc 2013; 2: e000279. [CrossRef] Khan MF, Movahed MR. Obesity cardiomyopathy and systolic functi- on: obesity is not independently associated with dilated cardiomyo- pathy. 2013; 18: 207-17.
  2. Rider OJ, Lewis AJ, Neubauer S. Structural and metabolic effects of obesity on the myocardium and the aorta. Obes Facts 2014; 7: 329- 38. [CrossRef] Zhang K, Huang F, Chen J, Cai Q, Wang T, Zou R, et al. Independent influence of overweight and obesity on the regression of left ventricu- lar hypertrophy in hypertensive patients: a meta-analysis. Medicine (Baltimore) 2014; 93: e130. [CrossRef] Lakhani M, Fein S. Effects of obesity and subsequent weight reduction on left ventricular function. Cardiol Rev 2011; 19: 1-4. [CrossRef] Meyer K. Central hemodynamics in obesity. Ther Umsch 2013; 70: 77-80. [CrossRef] Bella JN, Devereux RB, Roman MJ, O'Grady MJ, Welty TK, Lee ET, et al. Relations of left ventricular mass to fat-free and adipose body mass: the strong heart study. The Strong Heart Study Investigators. Circulati- on 1998; 98: 2538-44. [CrossRef] Lavie CJ, Patel DA, Milani RV, Ventura HO, Shah S, Gilliland Y. Impact of echocardiographic left ventricular geometry on clinical prognosis. Prog Cardiovasc Dis 2014; 57: 3-9. [CrossRef] Tanamas SK, Wong E, Backholer K, Abdullah A, Wolfe R, Barendregt J, et al. Duration of obesity and incident hypertension in adults from the Framingham Heart Study. J Hypertens 2015; 33: 542-5. [CrossRef] Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circula- tion 1977; 55: 613-8. [CrossRef] Head GA, Lim K, Barzel B, Burke SL, Davern PJ. Central nervous system dysfunction in obesity-induced hypertension. Curr Hypertens Rep 2014; 16: 466. [CrossRef] Hall JE, Brands MW, Hildebrandt DA, Kuo J, Fitzgerald S. Role of sympathetic nervous system and neuropeptides in obesity hyperten- sion. Braz J Med Biol Res 2000; 33: 605-18. [CrossRef] Alpert MA, Omran J, Mehra A, Ardhanari S. Impact of obesity and weight loss on cardiac performance and morphology in adults. Prog Cardiovasc Dis 2014; 56: 391-400. [CrossRef] Patel DA, Lavie