Journals / İstanbul Medical Journal / 2019 / Cilt: 20 - Sayı: 2

Radiotherapy in the Treatment of High Volume Chylous Fistula Following Hepatectomy: Case Report and Review of the Literature

Hepatektomi Sonrasında Gelişen Yüksek Debili Şilöz Fistül Tedavisinde Radyoterapi: Olgu ve Literatür Sunumu

Pages
152–155
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We believe thatlow-dose fractionated radiotherapy may be an alternativetreatment modality for refractory cases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Lymphatic injury is common in surgical procedures, but only1-11% of cases present with chylous fistula.
📊
Key Findings & Data:Here, we report a 58-year-old male patient withKlatskin tumor (Bismuth-Corlette, 3A) who had high volumechylous fistula after right hepatectomy.
💡
Conclusion & Impact:We believe thatlow-dose fractionated radiotherapy may be an alternativetreatment modality for refractory cases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Lymphatic injury is common in surgical procedures, but only1-11% of cases present with chylous fistula. Although highvolume chylous fistula is a rare condition after liver resection,serious life-threatening complications such as empyema andperitonitis secondary to severe mechanical, nutritional andimmunological disorders due to protein loss may accompanythis condition. Here, we report a 58-year-old male patient withKlatskin tumor (Bismuth-Corlette, 3A) who had high volumechylous fistula after right hepatectomy. In spite of medicaltreatment (fat-free diet, somatostatin) and tube drainage for 4weeks, daily chylous fistula ranged between 600-1800 cc/day.Due to the prolonged drainage, low-dose radiotherapy wasapplied to the patient. The patient underwent fractionatedradiotherapy protocol at a daily dose of 150 cGy (total 1200cGy) for 8 days. The drainage decreased to 150 cc on day 1,than to 50 cc on day 3 and the drain was removed on day 5.The patient has been under follow up without any problemfor 18 months. Several interventional and surgical multimodalprocedures have been described in the literature for thetreatment of refractory chylous fistulas. There are very fewstudies on radiotherapy in the literature. We believe thatlow-dose fractionated radiotherapy may be an alternativetreatment modality for refractory cases.

Özet

Lenfatik yaralanma cerrahi girişimler sırasında sıklıkla olmakla birlikte, olguların %1-11’inde şilöz fistül olarak karşımıza çıkmaktadır. Karaciğer rezeksiyonları sonrasında yüksek debili şilöz fistül nadiren görülen bir durum olmakla beraber, protein kaybına bağlı olarak ortaya çıkan ciddi mekanik, nütrisyonel ve immünolojik bozukluklar sonucunda ampiyem ve peritonit gibi yaşamı tehdit eden ciddi komplikasyonlar tabloya eşlik edebilir. Burada, 58 yaşındaki Klatskin tümörlü (Bismuth-Corlette, 3A) bir erkek hastamızda yaptığımız sağ hepatektomi sonrasında ortaya çıkan yüksek debili bir şilöz fistül olgusu sunulmuştur. Yapılan 4 haftalık tıbbi (yağdan fakir diyet, somatostatin) tedaviye ve tüp drenaja rağmen günlük şilöz fistülün 600- 1800 cc/gün arasında değişerek devam ettiği gözlendi. Sürecin uzaması nedeniyle, hastaya düşük doz radyoterapi uygulamasının yapılmasına karar verildi. Hastaya günlük 150 cGy fraksiyone dozda 8 günlük radyoterapi protokolü (toplam 1200 cGy) uygulandı. Uygulama sonrası 1. günde drenaj miktarı 150 cc’ye ve sonraki 3 günde toplam 50 cc’ye indi ve dren çekildi. Hasta post-operatif 18 aydır problemsiz izlenmektedir. Literatürde medikal tedaviye dirençli şilöz fistüllerin tedavisi amacıyla girişimsel ve cerrahi pek çok multimodal prosedür tanımlanmıştır. Tedavide radyoterapi uygulaması ile ilgili çalışmalar ise çok azdır. Olgumuzda uyguladığımız düşük doz farksiyonize radyoterapi uygulamasının tedaviye dirençli olgularda alternatif bir tedavi yöntemi olabileceğine inanıyoruz.

🔖

Cite This Article

DİLEK, O. N., ACAR, T., GÜR, E. Ö., AYDIN, A., ÇELİK, S. C., AKAY, H. S., HACIYANLI, M., TAVUSBAY, C. (2022). Radiotherapy in the Treatment of High Volume Chylous Fistula Following Hepatectomy: Case Report and Review of the Literature. İstanbul Medical Journal, Cilt: 20 - Sayı: 2, 152–155. https://ajindex.com/articles/551980

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Tessier DJ, Geibel J. Chyle fistula. In: http://emedicine.medscape.com/ article/190025-overview, 2015 2. Weniger M, D’Haese JG, Angele MK, Kleespies A, Werner J, Hartwig W. Treatment options for chylous ascites after major abdominal surgery: A systematic review. Am J Surg 2016
  2. Yılmaz M, Akbulut S, Işık B, Ara C, Özdemir F, Aydın C, et al. Chylous ascites after liver transplantation: Incidence and risk factors. Liver Transplantation 2012
  3. Baran M, Cakir M, Yüksekkaya HA, Arikan C, Aydin U, Aydogdu S, et al. Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. Transplant Proc 2008
  4. Steinemann DC, Dindo D, Clavien PA, Nocito A. Atraumatic chylous ascites: Systematic review on symptoms and causes. J Am Coll Surg 2011
  5. e1-4. 6. Sziklavari Z, Allgäuer M, Hübner G, Neu R, Ried M, Grosser C, et al. Radiotherapy in the treatment of postoperative chylothorax. J Cardiothoracic Surgery 2013
  6. Shiba H, Wakiyama S, Gocho T, Ishida Y, Misawa T, Yanaga K. A case of successful conservative treatment for chylous ascites after living-donor liver transplantation. Int Surg 2012
  7. Haberal M, Karakayali H, Moray G, Bilgin N. Surgical treatment of chylous ascites following partial living-related liver transplantation. Transpl Int 1998
  8. Kuboki S, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, et al. Chylous ascites after hepatopancreatobiliary surgery. Br J Surg 2013
  9. Matsumoto T, Yamagami T, Kato T, Hirota T, Yoshimatsu R, Masunami T, et al. The effectiveness of lymphangiography as a treatment method for various chyle leakages. Br J Radiol 2009
  10. Aalami OO, Allen DB, Organ CH Jr. Chylous ascites: a collective review. Surgery 2000
  11. Kaas R, Rustman LD, Zoetmulder FA. Chylous ascites after oncological abdominal surgery: incidence and treatment. Eur J Surg Oncol 2001
  12. Evans JG, Spiess PE, Kamat AM, Wood CG, Hernandez M, Pettaway CA, et al. Chylous ascites after postchemotherapy retroperitoneal lymph node dissection: review of the M. D. Anderson experience. J Urol 2006
  13. Dietl B, Pfister K, Aufschläger C, Kasprzak PM. Radiotherapy of inguinal lymphorrhea after vascular surgery. A retrospective analysis. Strahlenther Onkol 2005
  14. Habermehl D, Habl G, Eckstein HH, Meisner F, Combs SE. Radiotherapeutic management of lymph