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Journals / İstanbul Kuzey Klinikleri / 2016 / Cilt: 3 - Sayı: 3

Effect of HLA-DPA1 alleles on chronic hepatitis B prognosis and treatment response

Levent DOGANAY
Gizem DOGANAY DİNLER
Kamil OZDİL
Ilyas TUNCER
Oguzhan OZTURK
Seyma KATRİNLİ
Feruze ENC YILMAZ
Pages
168–174
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

However, HLA-DPA1*04:01 allele was significantly more frequently found in patients who redeveloped disease upon HBeAg seroconversion (100% vs 36.8%: p=0.037; Fisher's exact test).CONCLUSION: HLA-DPA1*04:01 allele may be a risk factor for reoccurrence of CHB after HBeAg seroconversion.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Chronic hepatitis B (CHB) is a major health problem.
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Key Findings & Data:The outcome of hepatitis B virus (HBV) infection is associated with variations in HLA-DPA1 alleles.
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Conclusion & Impact:However, HLA-DPA1*04:01 allele was significantly more frequently found in patients who redeveloped disease upon HBeAg seroconversion (100% vs 36.8%: p=0.037; Fisher's exact test).CONCLUSION: HLA-DPA1*04:01 allele may be a risk factor for reoccurrence of CHB after HBeAg seroconversion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Chronic hepatitis B (CHB) is a major health problem. The outcome of hepatitis B virus (HBV) infection is associated with variations in HLA-DPA1 alleles. The aim of this study was to investigate possible associations of HLA-DPA1 alleles with treatment response and with hepatitis B virus e antigen (HBeAg) seroconversion.METHODS: Eight different HLA-DPA1 alleles from 246 CHB patients were genotyped by polymerase chain reaction with sequence-specific primers at high resolution to investigate the association of HLA-DPA1 alleles with treatment response, development of cirrhosis, HBeAg seroconversion, and disease reoccurrence upon HBeAg loss.RESULTS: There was no significant association between HLA-DPA1 alleles and treatment response, development of cirrhosis, or HBeAg seroconversion. However, HLA-DPA1*04:01 allele was significantly more frequently found in patients who redeveloped disease upon HBeAg seroconversion (100% vs 36.8%: p=0.037; Fisher's exact test).CONCLUSION: HLA-DPA1*04:01 allele may be a risk factor for reoccurrence of CHB after HBeAg seroconversion.

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Cite This Article

DOGANAY, L., DİNLER, G. D., OZDİL, K., TUNCER, I., OZTURK, O., KATRİNLİ, S., YILMAZ, F. E. (2022). Effect of HLA-DPA1 alleles on chronic hepatitis B prognosis and treatment response. İstanbul Kuzey Klinikleri, Cilt: 3 - Sayı: 3, 168–174. https://ajindex.com/articles/551620

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