Journals / İstanbul Medical Journal / 2020 / Cilt: 21 - Sayı: 2

Electrocardiographic Alterations in Patients with Common Variable Immune Deficiency

Yaygın Değişken İmmün Yetmezliği Olan Hastalarda Elektrokardiyografik Değişikliklerin Değerlendirilmesi

Pages
109–114
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The number of patients with P terminalforce was also higher in the CVID group.Conclusion: As a result of this study, it was found that CVIDpatients have a higher incidence of developing arrhythmiathan normal healthy individuals.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Common variable immunodeficiency (CVID)is the most heterogeneous group among the antibodydeficiency syndromes, but its effects on the cardiovascularsystem have not yet been clearly identified.
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Key Findings & Data:Here, we aimedto investigate the arrhythmogenic effects of this disease withelectrocardiography.Methods: The study included 30 CVID patients and 30control subjects matched for age and comorbidities.Electrocardiographic and echocardiographic values of allparticipants were recorded.
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Conclusion & Impact:The number of patients with P terminalforce was also higher in the CVID group.Conclusion: As a result of this study, it was found that CVIDpatients have a higher incidence of developing arrhythmiathan normal healthy individuals.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Common variable immunodeficiency (CVID)is the most heterogeneous group among the antibodydeficiency syndromes, but its effects on the cardiovascularsystem have not yet been clearly identified. Here, we aimedto investigate the arrhythmogenic effects of this disease withelectrocardiography.Methods: The study included 30 CVID patients and 30control subjects matched for age and comorbidities.Electrocardiographic and echocardiographic values of allparticipants were recorded. QRS, QT, Tp-e were measuredmanually. QTc was calculated using Bazett’s formula. Then,Tp-e/QT, Tp-e/QTc, QT/QRS, and QTc/QRS ratios were calculatedand compared between the groups.Results: PR interval and P-wave dispersion were found to behigher in the CVID group. In addition, the QT interval andcorrected QT interval, T peak-to-end interval were higher inthe CVID arm, and the index of cardiac electrophysiologicalbalance value obtained with the QT/QRS ratio was also higherin the CVID group. The number of patients with P terminalforce was also higher in the CVID group.Conclusion: As a result of this study, it was found that CVIDpatients have a higher incidence of developing arrhythmiathan normal healthy individuals.

Özet

Amaç: Ortak değişken immün yetmezlik (CVID), antikor eksikliği sendromları arasında en heterojen gruptur, ancak kardiyovasküler sistem üzerindeki etkileri henüz net bir şekilde tanımlanamamıştır. Burada, bu hastalığın olası aritmojenik etkilerini, elektrokardiyografi ile değerlendirmeyi amaçladık. Yöntemler: Çalışmaya 30 CVID hastası ile yaş ve komorbiditeleri eşleşen 30 gönüllü kontrol grubu dahil edildi. Tüm katılımcıların elektrokardiyografik ve ekokardiyografik değerleri kaydedildi. QRS, QT, Tp-e manuel olarak ölçüldü. QTc, Bazett formülü kullanılarak hesaplandı. Daha sonra, Tp-e/QT, Tp-e/QTc, QT/QRS ve QTc/QRS oranları hesaplandı ve gruplar arasında karşılaştırılma yapıldı. Bulgular: CVID grubunda PR aralığı ve P dalga dispersiyonu daha yüksek bulundu. Ayrıca, QT aralığı ve düzeltilmiş QT aralığı, T peak-to-end interval, CVID kolunda daha yüksekti ve QT/QRS oranı ile elde edilen kardiyak elektrofizyolojik denge indeksi değeri CVID grubunda da daha yüksekti. CVID grubunda P terminal kuvveti olan hasta sayısı da daha fazla idi. Sonuç: Bu çalışma sonucunda, CVID hastalarının normal sağlıklı bireylere göre aritmi gelişme sıklığının daha yüksek olabileceği bulunmuştur.

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Cite This Article

ALSANCAK, Y., ÇÖLKESEN, F. (2022). Electrocardiographic Alterations in Patients with Common Variable Immune Deficiency. İstanbul Medical Journal, Cilt: 21 - Sayı: 2, 109–114. https://ajindex.com/articles/551422

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