SavedAdd your journal

Journals / İstanbul Kuzey Klinikleri / 2021 / Cilt: 8 - Sayı: 4

Epicardial fat thickness is associated with retinopathy in patients with newly diagnosed hypertension

Mehmet Gokhan Aslan
Oguzhan Ekrem Turan
Ali Gokhan Ozyildiz
Mustafa Cetin
Savas Ozer
Ahmet Seyda Yilmaz
Burcu Yucekul
Mustafa Kinik
Pages
365–370
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Increased EAT thickness is associated with the presence of retinopathy in hypertensive patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: Hypertensive retinopathy develops based on endothelial dysfunction, inflammation, and atherosclerosis.
📊
Key Findings & Data:METHODS: A total of 73 newly diagnosed hypertension (HT) patients were included in the study.
💡
Conclusion & Impact:CONCLUSION: Increased EAT thickness is associated with the presence of retinopathy in hypertensive patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Hypertensive retinopathy develops based on endothelial dysfunction, inflammation, and atherosclerosis. Epicardial fat secretes various cytokines associated with endothelial dysfunction, oxidative stress, inflammation, and atherosclerosis. We aimed to evaluate whether epicardial adipose tissue (EAT) thickness is a marker for retinopathy in newly diagnosed hypertensive patients. METHODS: A total of 73 newly diagnosed hypertension (HT) patients were included in the study. Transthoracic echocardiography (TTE) was used to measure EAT thickness. To evaluate the presence of retinopathy in HT patients, hypertensive retinopathy staging was performed by ophthalmologists, according to Scheie classification. RESULTS: Retinopathy was detected in 27 (37.0%) of 73 patients. EAT thickness in HT patients with retinopathy was higher than the group without retinopathy (5.07±1.45 mm vs. 4.19±1.20 mm, p=0.007). Low-density lipoprotein cholesterol (LDL-C) levels in HT patients with retinopathy were higher than the group without retinopathy (162.4±41.2 mg/dl vs. 138.1±35.6 mg/dl, p=0.010). As a result of the regression analysis, LDL-C (OR=1.016, 95% CI 1.001–1.031, p=0.043) and EAT thickness (OR=1.674, 95% CI 1.069–2.626, p=0.043) were the independent predictors of retinopathy. CONCLUSION: Increased EAT thickness is associated with the presence of retinopathy in hypertensive patients.

🔖

Cite This Article

Aslan, M. G., Turan, O. E., Ozyildiz, A. G., Cetin, M., Ozer, S., Yilmaz, A. S., Yucekul, B., Kinik, M. (2022). Epicardial fat thickness is associated with retinopathy in patients with newly diagnosed hypertension. İstanbul Kuzey Klinikleri, Cilt: 8 - Sayı: 4, 365–370. https://ajindex.com/articles/551277

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Walsh JB. Hypertensive retinopathy. Description, classification, and prognosis. Ophthalmology 1982;89:1127–31
  2. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology 1982;89:1132–45
  3. Pache M, Kube T, Wolf S, Kutschbach P. Do angiographic data support a detailed classification of hypertensive fundus changes? J Hum Hypertens 2002;16:405–10
  4. Klein R, Klein BE, Moss SE. The relation of systemic hypertension to changes in the retinal vasculature: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc 1997;95:329–48; discussion 348–50. 5. van Leiden HA, Dekker JM, Moll AC, Nijpels G, Heine RJ, Bouter LM, et al. Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study. Arch Ophthalmol 2003;121:245– 51
  5. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004;351:2310–7. 7. 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens 1999;17:151–83
  6. Ramsay LE, Williams B, Johnston GD, MacGregor GA, Poston L, Potter JF, et al. British Hypertension Society guidelines for hypertension management 1999: summary. BMJ 1999;319:630–5
  7. August P. Initial treatment of hypertension. N Engl J Med 2003;348:610–7
  8. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 2009;10:165– 93
  9. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450–8
  10. Kane GC, Karon BL, Mahoney DW, Redfield MM, Roger VL, Burnett JC Jr, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA 2011;306:856–63
  11. Yarlioglues M, Kaya MG, Ardic I, Dogdu O, Yarlioglues H, Zencir C, et al. Dose-dependent acute effects of passive smoking on left ventricular cardiac functions in healthy volunteers. J Investig Med 2012;60:517–22
  12. Turan E, Kırboğa K, Turan Y, Göçmen AY. Pentraxin 3 and epicardial fat thickness are independently associated with diabetic retinopathy in diabetic patients. Int J Diabetes Dev Ctries 2019;39:499–505
  13. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al; ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018