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Journals / İstanbul Kuzey Klinikleri / 2021 / Cilt: 8 - Sayı: 6

Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score

Seref ALPSOY
Demet Ozkaramanli GUR
Aydin AKYÜZ
Muhammet Mucip EFE
Beysim MERT
Huseyin AYKAÇ
Savas GÜZEL
Pages
607–614
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In multivariate analysis, DM (OR=0.463; CI: 0.184–0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its’ cardiovascular protective effects.
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Key Findings & Data:METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion.
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Conclusion & Impact:In multivariate analysis, DM (OR=0.463; CI: 0.184–0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its’ cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0–1 into the poor CCC group (n=45) and Rentrop 2–3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882–37741] pg/ml and (17504 [813–47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813–29398] pg/ml) than those without diabetes (n=45; 19724 [865–47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184–0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity

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Cite This Article

ALPSOY, S., GUR, D. O., AKYÜZ, A., EFE, M. M., MERT, B., AYKAÇ, H., GÜZEL, S. (2022). Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score. İstanbul Kuzey Klinikleri, Cilt: 8 - Sayı: 6, 607–614. https://ajindex.com/articles/551241

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