Journals / İstanbul Medical Journal / 2020 / Cilt: 21 - Sayı: 1

Fever of Unknown Origin: A Patient with Intermittent Idiopathic Fever for Three Years

Nedeni Bilinmeyen Ateş: Üç Yıldır Ateşi Olan Bir Hasta

Pages
23–25
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

She had bone morrow biopsy and was diagnosed with T-cell large granular lymphocytic leukaemia.

📌 3 Key Takeaways

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Objective & Hypothesis:Fever of unknown origin (FUO) is defined as a fever ≥38.3 ºC on at least three occasions over a period of at least three weeks, with no obvious diagnosis despite one week of inpatient investigations.
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Key Findings & Data:Over 200 infections, neoplasm and inflammatory diseases can lead to an FUO.
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Conclusion & Impact:She had bone morrow biopsy and was diagnosed with T-cell large granular lymphocytic leukaemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Fever of unknown origin (FUO) is defined as a fever ≥38.3 ºC on at least three occasions over a period of at least three weeks, with no obvious diagnosis despite one week of inpatient investigations. Over 200 infections, neoplasm and inflammatory diseases can lead to an FUO. The definition of FUO is difficult, even though more sophisticated diagnostic tools such as positron emitted tomography and many biochemical and serological assays have become routinely available. However, it is surprising that despite the improvement in diagnostic modalities, some FUO still remain undiagnosed. When the diagnosis of FUO was not defined, invasive tests such as biopsies may be useful. Bone marrow biopsy is an accepted method in FUO to uncover haematological malignancies and certain infections. We report a case of prolonged fever 4-5 times each year for 3 years which has presented FUO. She had bone morrow biopsy and was diagnosed with T-cell large granular lymphocytic leukaemia.

Özet

Nedeni bilinmeyen ateş; ayaktan hastalarda en az üç hafta hastanede bir hafta süre ile tetkik edilmesine rağmen en az üç ölçümde ateşin ≥38,3 ºC’nin üzerinde olduğu durum olarak tanımlanır. Enfeksiyonlar, maliniteler, enflamatuvar hastalıklar olmak uzere 200 üzerinde hastalık nedeni bilinmeyen ateşin nedeni olabilir. Pozitron yayınlayıcı tomografi ve birçok biyokimyasal, serolojik ilerlemiş tanı metotlarının rutin olarak kullanılmasına rağmen nedeni bilinmeyen ateşin tanısını koymak zordur. Nedeni bilinmeyen ateşin ilerlemiş tanı metotlarına rağmen tanısı konulamadığında biyopsi gibi invazif girişimler yapılır. Kemik iliği biyopsisi ile hemotolojik maliniteler ve bazı enfeksiyonların tanısı konulabilir. Son 3 yılda, senede 4-5 kez ateşi olan bir nedeni bilinmeyen ateş olgusunu sunuyoruz. Hastada hematolojik bir malinite; T-hücre büyük granüllü lenfatik lösemi tanısı kemik iliği biyopsisi ile konuldu.

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Cite This Article

Altunoğlu, E., Doğu, M. H., Çelik, D. C., Hekimoğlu, S., Özsoy, E. (2022). Fever of Unknown Origin: A Patient with Intermittent Idiopathic Fever for Three Years. İstanbul Medical Journal, Cilt: 21 - Sayı: 1, 23–25. https://ajindex.com/articles/551072

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