Journals / İstanbul Medical Journal / 2021 / Cilt: 22 - Sayı: 3

Renal Glomerular Hyperfiltration is Associated with Poor Prognosis in Acute ST-Elevation Myocardial Infarction

Renal Glomerüler Hiperfiltrasyon Akut ST-Yükselmeli Miyokard İnfarktüsünde Kötü Prognoz ile İlişkilidir

Pages
180–185
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

High andlow GFRs led to higher risks of developing major cardiovascularevents [odds ratio (OR): 1.92, 95% confidence interval (CI):1.19-3.08, p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Glomerular hyperfiltration is related to severalclinical conditions, such as prediabetes and prehypertension,and associated with poor prognosis in long-term follow-up.
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Key Findings & Data:Thisstudy aims to elucidate the relationship between glomerularhyperfiltration and short-term prognosis in patients with ST-segment elevation myocardial infarction (STEMI) treated bypercutaneous coronary intervention (PCI).Methods: A total of 1,402 patients (24% women, n=338) whohad been diagnosed with STEMI and treated by primary PCIwere enrolled in the present study.
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Conclusion & Impact:High andlow GFRs led to higher risks of developing major cardiovascularevents [odds ratio (OR): 1.92, 95% confidence interval (CI):1.19-3.08, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Glomerular hyperfiltration is related to severalclinical conditions, such as prediabetes and prehypertension,and associated with poor prognosis in long-term follow-up. Thisstudy aims to elucidate the relationship between glomerularhyperfiltration and short-term prognosis in patients with ST-segment elevation myocardial infarction (STEMI) treated bypercutaneous coronary intervention (PCI).Methods: A total of 1,402 patients (24% women, n=338) whohad been diagnosed with STEMI and treated by primary PCIwere enrolled in the present study. Glomerular hyperfiltrationwas defined an estimated glomerular filtration rate (GFR) abovethe 95th percentile based on age- and sex-specific distributions,and a low-filtration rate was defined as an estimated GFR belowthe 5th percentile. GFR was assessed using the Chronic KidneyDisease Epidemiology Collaboration equation. The majoradverse cardiovascular events (MACE) considered in this workincluded acute stent thrombosis, re-infarction, cardiogenicshock, and cardiac death within 30 days.Results: MACE was observed in 178 patients (12.6%). High andlow GFRs led to higher risks of developing major cardiovascularevents [odds ratio (OR): 1.92, 95% confidence interval (CI):1.19-3.08, p

Özet

Amaç: Glomerüler hiperfiltrasyonun pre-diabetes, pre- hipertansiyon gibi birçok klinik durumla ilişkili olduğu ve uzun dönem takipte daha kötü prognoz ile ilişkili olduğu bilinmektedir. Amacımız perkütan koroner girişimlerle (PKG) tedavi edilen ST-segment yükselmeli miyokard enfarktüslü (STYME) hastalarda glomerüler hiperfiltrasyon ile kısa dönem prognoz arasındaki ilişkiyi aydınlatmaktır. Yöntemler: STYME tanısı alan ve primer PKG ile tedavi edilen toplam 1.402 hasta (%24 kadın n=338) bu çalışmaya dahil edildi. Glomerüler hiperfiltrasyon, yaşa ve cinsiyete göre dağılımda 95. persentilin üzerindeki değerler olarak tanımlanırken, düşük filtrasyon hızı 5. persentilin altındakiler olarak tanımlandı. Glomerüler filtrasyon oranı Chronic Kidney Disease Epidemiology Collaboration equation formülüne göre hesaplandı. Majör kardiyovasküler olaylar 30 gün içerisindeki akut stent trombozu, re-infarkt, kardiyojenik şok ve kardiyak ölümden oluştu. Bulgular: Yüz yetmiş sekiz hastada (%12,6) majör kardiyovasküler olaylar gelişti. Hem düşük hem de yüksek glomerüler filtrasyon oranı, majör kardiyovasküler olay gelişiminde [olasılık oranı (OR): 1,92 %95 güven aralığı (CI): 1,19-3,08, p

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Cite This Article

DURMUŞ, G., YELGEÇ, N. S., KARATAŞ, M. B., GÜZELBURÇ, Ö., EMRE, A., ÇANGA, Y., ZENGİN, A. (2022). Renal Glomerular Hyperfiltration is Associated with Poor Prognosis in Acute ST-Elevation Myocardial Infarction. İstanbul Medical Journal, Cilt: 22 - Sayı: 3, 180–185. https://ajindex.com/articles/550990

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