Journals / İstanbul Kanuni Sultan Süleyman Tıp Dergisi / 2022 / Cilt: 14 - Sayı: 1

Relationship of Endothelial Cell Density and Morphology with Topographic Anterior Segment Parameters in Pediatric Population

Pediyatrik Popülasyonda, Endotelyal Hücre Yoğunluğunun ve Morfolojisinin, Topografik Ön Segment Parametreleri ile İlişkisi

Pages
70–76
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the pediatric Turkish patient population, while a decrease in ECD was detected with increasing age, there was no change in HCR.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The primary aim of the study is to investigate whether there is a relationship between endothelial cell density (ECD) and morphology with topographic anterior segment parameters in the pediatric population.
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Key Findings & Data:Method: For the cross-sectional observational study, 73 eyes of 73 children with no ocular pathology except myopia and hyperopia up to 3 D were included.
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Conclusion & Impact:In the pediatric Turkish patient population, while a decrease in ECD was detected with increasing age, there was no change in HCR.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The primary aim of the study is to investigate whether there is a relationship between endothelial cell density (ECD) and morphology with topographic anterior segment parameters in the pediatric population. The secondary aim of the study is to determine the normative morphological and topographic parameters of the cornea and anterior segment in a healthy pediatric Turkish population. Method: For the cross-sectional observational study, 73 eyes of 73 children with no ocular pathology except myopia and hyperopia up to 3 D were included. ECD, hexagonal cell ratio (HCR), and other morphological parameters were measured using the NIDEK CEM-530 specular microscopy device. Iris diameter, anterior chamber depth (ACD), anterior chamber volume (ACV), corneal volume, and other anterior segment parameters were measured using the Sirius corneal topography device. Results: The mean age of 73 patients was 11±3 years. The spherical equivalent mean was –0.24±1.28 D. The mean ECD was 3253±308 cells/mm2, and the HCR was 67 6%. Mean values of iris diameter, ACD, ACV, and corneal volume were 12.2±0.3 mm, 3.8±0.2, 159±25 mm3, and 58±3 mm3, respectively. There was no statistically significant correlation between ECD and HCR with topographic anterior segment parameters. There was a negative and significant correlation between age and ECD (r=–0.55, p=0.000), but no significant correlation was found between age and HCR (p=0.26). Conclusion: In the pediatric age group, there was no correlation between topographic anterior segment parameters and ECD and HCR. In the pediatric Turkish patient population, while a decrease in ECD was detected with increasing age, there was no change in HCR.

Özet

Amaç: Pediyatrik popülasyonda, endotel hücre yoğunluğu ve morfolojisi ile topografik ön segment parametreleri arasında ilişki varlığını araştırmak çalışmanın birincil amacıdır. Sağlıklı pediyatrik Türk popülasyonunda, kornea ve ön segmentin normotif morfolojik ve topografik parametrelerini saptamak, çalışmanın ikincil amacıdır. Yöntem: Kesitsel gözlemsel çalışma için, üç diyoptriye kadar miyopi ve hipermetropi dışında göz patolojisi olmayan, 73 çocuğun 73 gözü çalışmaya dahil edildi. Endotel hücre yoğunluğu, hekzagonal hücre oranı ve diğer morfolojik parametreler NİDEK CEM-530 speküler mikroskop cihazı ile ölçüldü. İris çapı, ön kamara derinliği, ön kamara hacmi, kornea hacmi ve diğer ön segment parametreleri Sirius kornea topografi cihazı ile ölçüldü. Bulgular: Yetmiş üç çocuğun yaş ortalaması 11±3 yıl olarak saptandı. Sferik eş değer ortalaması –0,24±1,28 diyoptri saptandı. Endotel hücre yoğunluğu ortalaması 3253±308 hücre/mm2, hekzagonal hücre oranı %67±6 olarak saptandı. İris çapı 12,2±0,3 mm, ön kamara derinliği 3,8±0,2 mm, ön kamara hacmi 159±25 mm3, kornea hacmi 58±3 mm3 olarak saptandı. Endotel hücre yoğunluğu ve hekzagonal hücre oranı ile topografik ön segment parametreleri arasında istatistiksel olarak anlamlı korelasyon saptanmadı. Yaş ile endotel hücre yoğunluğu arasında negatif yönde ve istatistiksel olarak anlamlı (r=–0,55, p=0,000) bir korelasyon saptanırken, yaş ile hekzagonal hücre oranı arasında istatistiksel olarak anlamlı korelasyon saptanmadı (p=0,26). Sonuç: Çalışmamızda, pediyatrik yaş grubunda topografik ön segment parametreleri ile endotel hücre yoğunluğu ve hekzagonal hücre oranı arasında anlamlı korelasyon saptanmadı. Yaşın artışı ile birlikte endotel hücre yoğunluğunda azalma saptanırken, hekzagonal hücre oranında değişiklik saptanmadı.

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Cite This Article

ERDOĞAN, M., SARİCİ, K., BAYRAMOĞLU, S. E., SAYIN, N., ARTIŞ, G., ÖZDEMİR, A. (2022). Relationship of Endothelial Cell Density and Morphology with Topographic Anterior Segment Parameters in Pediatric Population. İstanbul Kanuni Sultan Süleyman Tıp Dergisi, Cilt: 14 - Sayı: 1, 70–76. https://ajindex.com/articles/550881

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