Journals / İstanbul Medical Journal / 2020 / Cilt: 21 - Sayı: 2

Smoking is a Strong Independent Predictor of Acute Coronary Syndrome Among Patients with Coronary Artery Ectasia

Koroner Arter Ektazisi Olan Hastalarda Akut Koroner Sendromun Güçlü Bağımsız Bir Öngördürücüsü: Sigara

Pages
92–96
Publication Date
2022-10-19
DOI
—
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In multivariate logistic regression analysis, whenhypertension, DM, age, gender and smoking were evaluatedtogether, smoking was strongly predictive of ACS in patientswith ectasic coronary artery [odds ratio: 2.34, (95% confidenceinterval), 1.093-4.983, p=0.028].Conclusion: When the factors that play an important role inthe etiology of ACS are evaluated together in patients with CAE,smoking predicts ACS strongly and independently.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The independent relationship between smokingand Acute Coronary syndrome (ACS), among other risk factors,was investigated in patients with ectasic coronary arteries.Methods: Between June 2015 and August 2018, 10.320coronary angiography processes performed in our clinic wereanalyzed retrospectively.
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Key Findings & Data:Coronary artery ectasia (CAE) wasdefined as the enlargement of a coronary artery to 1.5 times ormore than that of the local or adjacent normal coronary arterysegment.
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Conclusion & Impact:In multivariate logistic regression analysis, whenhypertension, DM, age, gender and smoking were evaluatedtogether, smoking was strongly predictive of ACS in patientswith ectasic coronary artery [odds ratio: 2.34, (95% confidenceinterval), 1.093-4.983, p=0.028].Conclusion: When the factors that play an important role inthe etiology of ACS are evaluated together in patients with CAE,smoking predicts ACS strongly and independently.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: The independent relationship between smokingand Acute Coronary syndrome (ACS), among other risk factors,was investigated in patients with ectasic coronary arteries.Methods: Between June 2015 and August 2018, 10.320coronary angiography processes performed in our clinic wereanalyzed retrospectively. Coronary artery ectasia (CAE) wasdefined as the enlargement of a coronary artery to 1.5 times ormore than that of the local or adjacent normal coronary arterysegment. Patients were divided into two groups with (group 1)and without ACS (group 2). The two groups were compared interms of demographic characteristics, laboratory findings andmajor risk factors such as hypertension, diabetes mellitus (DM)and smoking. Multivariate logistic regression analysis was usedto evaluate independent predictors of ACS in patients with CAE.Results: There were 189 (1.8%) patients with CAE and 143 (76%)of them were male. Of the patients, 107 (57%) were smoking,106 (56%) had hypertension and 43 (22%) had DM. Onehundred two (54%) of the patients presented with ACS. Therewas no significant difference between the groups in terms ofhypertension, DM and basic laboratory characteristics. Smokingrate was significantly higher in the ACS group (66% and 34%,p=0.001). In multivariate logistic regression analysis, whenhypertension, DM, age, gender and smoking were evaluatedtogether, smoking was strongly predictive of ACS in patientswith ectasic coronary artery [odds ratio: 2.34, (95% confidenceinterval), 1.093-4.983, p=0.028].Conclusion: When the factors that play an important role inthe etiology of ACS are evaluated together in patients with CAE,smoking predicts ACS strongly and independently.

Özet

Amaç: Ektazik koroner arterlere sahip hastalarda, diğer önemli risk faktörlerinin yanında sigara ile Akut Koroner sendrom (AKS) arasındaki bağımsız ilişki araştırıldı. Yöntemler: Kliniğimizde Haziran 2015-Ağustos 2018 tarihleri arasında yapılan 10.320 adet koroner anjiyografi geriye doğru analiz edildi. Koroner arter ektazisi, koroner arterin bölgesel ya da komşu normal koroner arter segmentinin 1,5 katı veya daha fazlası olacak şekilde genişlemesi olarak tanımlandı. Hastalar AKS olan ve olmayan olarak iki gruba ayrıldı. İki grup demografik özellikler, laboratuvar bulguları ve hipertansiyon, diabetes mellitus (DM) ve sigara gibi majör risk faktörleri açısından karşılaştırıldı. Çok değişkenli lojistik regresyon analizi ile ektazik koroner arterlere sahip hastalarda AKS’yi bağımsız öngördürücü risk faktörleri değerlendirildi. Bulgular: Yüz kırk üçü erkek (%76), toplam 189 adet (%1,8) koroner ektaziye sahip hasta saptandı. Ektazi görülen hastaların 106’sı (%56) hipertansiyon, 43’ü (%22) DM tanılıydı ve 107’si (%57) sigara içmekteydi. Hastalardan 102’si (%54) AKS kliniği ile başvurdu. AKS olan (grup 1), AKS olmayan (grup 2) ile karşılaştırıldığında hipertansiyon, DM ve temel laboratuvar özellikleri açısından gruplar arasında anlamlı fark yoktu. Grup 1 daha genç (58±13 ve 63±10, p=0,016) ve erkek (%82 ve %67, p=0,027) ağırlıklıydı. AKS olan grupta sigara içme oranı anlamlı olarak yüksekti (%66 ve %34, p=0,001). Çok değişkenli lojistik regresyon analizinde hipertansiyon, DM, yaş, cinsiyet ve sigara birlikte değerlendirildiğinde, sigaranın ektazik koroner arterli hastalarda AKS’yi güçlü bağımsız bir şekilde öngördürdüğü saptandı [odds ratio: 2.34, (%95 güven aralığı), 1.093-4.983, p=0,028]. Sonuç: Ektazik koroner arterlere sahip hastalarda, AKS etiyolojisinde önemli rol oynayan etkenler birlikte değerlendirildiğinde, sigara AKS’yi güçlü ve bağımsız bir şekilde öngördürmektedir.

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Cite This Article

SIĞIRCI, S., GÜRDAL, A., KILIÇKESMEZ, K. O. (2022). Smoking is a Strong Independent Predictor of Acute Coronary Syndrome Among Patients with Coronary Artery Ectasia. İstanbul Medical Journal, Cilt: 21 - Sayı: 2, 92–96. https://ajindex.com/articles/550288

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