Journals / İstanbul Kanuni Sultan Süleyman Tıp Dergisi / 2015 / Cilt: 7 - Sayı: 2

Diffuse Gastric Adenocarcinoma-Linitis Plastica

Mide Diffüz Adenokarsinomu-Linitis Plastika

Pages
47–52
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

On the other hand, surgery with chemotheraphy and radiotheraphy are suggested by many authors.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Linitis Plastica (LP) is a type of adenocarcinoma which can be detected anywhere in gastrointestinal system and characterized by diffuse spread of tumor cells into the submucosa and muscular layer.
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Key Findings & Data:Undifferentiated tumor cells infiltrate all gastric wall with reactive fibrosis and gastric wall become thick and rigid.
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Conclusion & Impact:On the other hand, surgery with chemotheraphy and radiotheraphy are suggested by many authors.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Linitis Plastica (LP) is a type of adenocarcinoma which can be detected anywhere in gastrointestinal system and characterized by diffuse spread of tumor cells into the submucosa and muscular layer. It is detected most commonly in stomach. Undifferentiated tumor cells infiltrate all gastric wall with reactive fibrosis and gastric wall become thick and rigid. The disease spreads very quickly through lymphatic route to the nearby organs or cause peritoneal carcinomatosis. In addition to classical symptoms of gastric cancer, it is usually represented with early satiety, dyspepsia and reflux. Upper gastrointestinal system endoscopy, endoultrasonography, computed tomography and diagnostic laparoscopy are important tools in the diagnosis of LP. Deeper biopsies are recommended in endoscopic interventions. The treatment of LP has been extensively discussed in the literature. Some authors claimed that surgery does not improve long term survey in LP. On the other hand, surgery with chemotheraphy and radiotheraphy are suggested by many authors.

Özet

Linitis Plastika (LP), tüm gastrointestinal sistemde görülebilen, submukoza ve musküler tabakaya diffüz olarak yayılan adenokarsinom türüdür. En sık midede görülür. Kötü diferansiye tümör hücrelerinin midenin tamamını infiltre etmesi sonucu, reaktif fibrozise bağlı mide duvarı kalınlaşıp, sert bir hâl alır. Hastalık, lenfatik yayılım yoluyla ve komşu organların içine doğru lokal olarak genişleyerek ya da peritoneal karsinomatoza yol açarak erken dönemde hızla yayılır. Mide kanserinin klasik semptomlarının yanında genişleyemeyen mide nedeni ile erken doygunluk, şişkinlik ve özofagusa reflü gibi yakınmalar görülür. LP tanısında üst gastrointestinal sistem endoskopisi, endoultrasonografi, bilgisayarlı tomografi ve tanısal laparoskopi değerlidir. Endoskopik işlemlerde derin biyopsiler alınması önerilir. LP tedavisi literatürde tartışmalıdır. Cerrahi tedavinin uzun dönem yaşam süresini arttırmadığını iddia eden çalışmalar mevcuttur. Diğer taraftan cerrahi ile birlikte kemoterapi ve radyoterapi uygulamalarının önerilmektedir.

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Cite This Article

VELİDEDEOĞLU, M., KAYA, B., ŞENER, A., CEZİK, A. (2022). Diffuse Gastric Adenocarcinoma-Linitis Plastica. İstanbul Kanuni Sultan Süleyman Tıp Dergisi, Cilt: 7 - Sayı: 2, 47–52. https://ajindex.com/articles/549304

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