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Journals / İnönü üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi / 2020 / Cilt: 8 - Sayı: 2

VOLTAMMETRIC ANALYSIS OF MELATONIN AND DOPAMINE BY USING GRAPHENE OXIDE/POLYIMIDE BASED BIOSENSOR

Grafen Oksit/Poliimid Temelli Biyosensör Kullanarak Melatonin ve Dopaminin Voltametrik Analizi

Turgay SEÇKİN
Öznur GÜNGÖR
Aziz PAŞAHAN
Büşra AKSOY
Süleyman KÖYTEPE
Pages
367–382
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The obtained results indicated that while uric acid (UA) is present in the medium, GO/PI composite can be used as an excellent membrane in the design of voltammetric sensors to analyze MET and DP simultaneously.

📌 3 Key Takeaways

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Objective & Hypothesis:In this research, for the simultaneous analysis of melatonin (MET) and dopamine (DP), graphene oxide/polyimide (GO/PI) composite electrode was prepared with the modification of Pt electrode.
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Key Findings & Data:Firstly, GO/PI composite structure was synthesized from 2,6-diaminopyridine based polyimide and 5% GO.
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Conclusion & Impact:The obtained results indicated that while uric acid (UA) is present in the medium, GO/PI composite can be used as an excellent membrane in the design of voltammetric sensors to analyze MET and DP simultaneously.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dopamin · Elektrokimyasal biyosensör · Grafen oksit/poliimid kompozit

Abstract

In this research, for the simultaneous analysis of melatonin (MET) and dopamine (DP), graphene oxide/polyimide (GO/PI) composite electrode was prepared with the modification of Pt electrode. Firstly, GO/PI composite structure was synthesized from 2,6-diaminopyridine based polyimide and 5% GO. Then, the obtained composite structure as the membrane was coated on the electrode surface. MET and DP responses of the prepared GO/PI composite electrode were investigated by Differential Pulse Voltammetry (DPV) technique. Linearity was obtained over a concentration range of 85-105 µM for MET (R2 = 0.9976). For DP analysis, the linearity was also monitored over a concentration range of 85-105 µM (R2=0.9988). The detection limits of GO/PI modified electrode were approximately 13.45×10−5 M and 9.61×10−5 M for MET and DP, respectively. The prepared GO/PI composite modified electrode exhibited good repeatability, wide linear range and sensitivity for MET and DP. The obtained results indicated that while uric acid (UA) is present in the medium, GO/PI composite can be used as an excellent membrane in the design of voltammetric sensors to analyze MET and DP simultaneously.

Özet

Bu araştırmada, melatonin (MET) ve dopaminin (DP) eş zamanlı analizi için, Pt elektrodun modifikasyonu ile grafen oksit/poliimit (GO/PI) kompozit elektrot hazırlanmıştır. İlk olarak, GO/PI kompozit yapısı, 2,6-diaminopiridin temelli PI ve % 5 GO'den sentezlenmiştir. Daha sonra membran olarak elde edilen kompozit yapı elektrot yüzeyi üzerine kaplanmıştır. Hazırlanan GO/PI kompozit elektrodunun MET ve DP yanıtları Diferansiyel Puls Voltametri (DPV) tekniği ile araştırılmıştır. MET ölçümleri için doğrusallık 85- 105 µM (R2=0.9976) konsantrasyon aralığında elde edilmiştir. DP analizi için de doğrusallık 85-105 µM konsantrasyon aralığında izlenmiştir (R2=0.9988). GO/PI ile modifiye edilmiş elektrodun tayin limitleri, MET ve DP için sırasıyla yaklaşık 13.45x10−5 M ve 9.61x10−5 M’dı. Hazırlanan GO/PI kompozit modifiye elektrot, MET ve DP için iyi tekrarlanabilirlik, geniş doğrusal aralık ve hassasiyet sergilemiştir. Elde edilen sonuçlar, GO/PI kompozitinin ortamda ürik asit (UA) varlığında, MET ve DP’i eş zamanlı olarak analiz etmek için mükemmel bir membran olarak kullanılabileceğini göstermiştir.

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Cite This Article

SEÇKİN, T., GÜNGÖR, Ö., PAŞAHAN, A., AKSOY, B., KÖYTEPE, S. (2022). VOLTAMMETRIC ANALYSIS OF MELATONIN AND DOPAMINE BY USING GRAPHENE OXIDE/POLYIMIDE BASED BIOSENSOR. İnönü üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, Cilt: 8 - Sayı: 2, 367–382. https://ajindex.com/articles/548365

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