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Journals / İnfeksiyon Dergisi / 1997 / Cilt: 11 - Sayı: 1

The role of antioxidants and lipid peroxides in experimental meningitis and interaction of ceftriaxone with diclofenac sodium

Deneysel meninjitte lipit peroksitleriyle antioksidanların rolü ve seftriakson- diklofenak sodyum ile etkileşimi

Yıldız ATAMER
Yüksel KOÇYİĞİT
Aytaç ATAMER
Mahmut METE
Adnan CEVİZ
Salih HOŞOĞLU
Pages
43–47
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

GSH-Px was lowered in meningitis (M) and ceftriaxone (C) groups with p

📌 3 Key Takeaways

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Objective & Hypothesis:In the brain tissues of experimentally acute bacterial meningitis induced rats; the alterations in Iipid peroxidation indicators, malondialdehyde: (MDA), antiperoxidant glutathione, (GSH) and glutathione peroxidase (GSH-Px) and also the effect of six-day therapy with ceftriaxone and diclophenac sodium upon these parameters were studied.
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Key Findings & Data:Totally 46 rats were studied.The rats were divided into four groups: Meningitis group (n=7), ceftriaxone group (n=14, 30 mg/kg/day), ceftriaxone + diclophenac sodium (n=15, 30 mg/kg/day), and control group (n= 10).
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Conclusion & Impact:GSH-Px was lowered in meningitis (M) and ceftriaxone (C) groups with p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the brain tissues of experimentally acute bacterial meningitis induced rats; the alterations in Iipid peroxidation indicators, malondialdehyde: (MDA), antiperoxidant glutathione, (GSH) and glutathione peroxidase (GSH-Px) and also the effect of six-day therapy with ceftriaxone and diclophenac sodium upon these parameters were studied. Totally 46 rats were studied.The rats were divided into four groups: Meningitis group (n=7), ceftriaxone group (n=14, 30 mg/kg/day), ceftriaxone + diclophenac sodium (n=15, 30 mg/kg/day), and control group (n= 10). Except the meningitis and control groups, the other two groups, received the antibiotic and antiinflammatory for six days. The meningitis group received only saline 0.4 mg/day. At the and of applications all rats were sacrificed and their tissues were studied. When compared with the control group, MDA levels were found to be significantly elevated (p < 0.001) and GSH lowered (p < 0.001) in all other groups. GSH-Px was lowered in meningitis (M) and ceftriaxone (C) groups with p

Özet

Deneysel olarak akut bakteriyel menenjit (ABM) oluşturulan sıkanların beyin dokusunda, lipit peroksidasyonunun bir göstergesi olan malondialdehit (MDA), antiperoksidant glutatyon (GSH_), glutatyon peroksidaz (GSH-Px) değişiklikleriyle, tedavi olarak 6 gün uygulanan seftriakson ve diklofenak sodyum'un bu parametrelere etkisi incelendi. Toplam 46 sıçan, kontrol (n=10), meninjit (n=7), seftriakson (30 mg/kg/gün, n=14) ve seftriakson+diklofenak sodyum (30mg/kg/gün + 0.5 mg/gün,, n=15) olmak üzere 4 gruba ayrıldı. Kontrol ve meninjit grubu dışındaki sıçanlara altı gün süresince anti-enflamatuvar ve antibiyotik uygulandı, meninjit grubuna sadece 0.4 mg/gün serum fizyolojik intraperitoneal olarak verildi. Uygulama sonunda tüm hayvanlar öldürülerek doku örnekleri alındı. Kontrollere göre, tüm grupların MDA düzeylerinin önemli derecede yüksek (p < 0.001) olduğu, GSH düzeylerinin düştüğü (p

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Cite This Article

ATAMER, Y., KOÇYİĞİT, Y., ATAMER, A., METE, M., CEVİZ, A., HOŞOĞLU, S. (2022). The role of antioxidants and lipid peroxides in experimental meningitis and interaction of ceftriaxone with diclofenac sodium. İnfeksiyon Dergisi, Cilt: 11 - Sayı: 1, 43–47. https://ajindex.com/articles/547105

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