Journals / İnfeksiyon Dergisi / 1998 / Cilt: 12 - Sayı: 3

Investigation of the correlation between proteinase activity of candida albicans strains and vulvovaginal candidosis

Candida albicans suşlarının proteinaz aktivitesi ile vulvovajinal kandidoz arasındaki ilişkinin araştırılması

Pages
389–392
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The difference in proteinase secretion between the isolates from the two groups of women demonstrates the existence of a correlation between proteinase production and vaginal candidosis caused by C. albicans.

📌 3 Key Takeaways

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Objective & Hypothesis:In order to investigate whether there is a correlation between the proteinase activity of Candida strains and vulvovaginal candidosis, this study was carried out.
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Key Findings & Data:Proteinase production was assayed in bovine serum albumin agar (pH 4.5).
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Conclusion & Impact:The difference in proteinase secretion between the isolates from the two groups of women demonstrates the existence of a correlation between proteinase production and vaginal candidosis caused by C. albicans.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In order to investigate whether there is a correlation between the proteinase activity of Candida strains and vulvovaginal candidosis, this study was carried out. Candida albicans isolates from nondiabetic, nonpregnant outpatients with vaginitis were compared with isolates from women without specific candidat vaginitis symptomatology (carriers) for in vitro proteinase secretion. Proteinase production was assayed in bovine serum albumin agar (pH 4.5). Out of 31 isolates from patients with vaginitis seven strains had the top score 1+ and 24 strains 2+; out of 25 isolates from carriers (control) group 17 strains had the top score 1+ and only two strains 2+. The isolates from patients were more proteolytic than those from carriers and difference between the two groups were found statistically significant (p < 0.001). The difference in proteinase secretion between the isolates from the two groups of women demonstrates the existence of a correlation between proteinase production and vaginal candidosis caused by C. albicans.

Özet

Candida suslannm proteinaz aktivitesi ile vulvovaginal kandidoz oluşması arasında bir ilişkinin olup olmadığını saptamak amacıyla çalışma yapılmıştır. Diyabetik ve gebe olmayan vajinitli hastalarla spesifik vagina kandidozu vajinit belirtileri olmayan (taşıyıcı) kadınlardan izole edilen Candida albicans suslannm proteinaz aktivitesi in vitro koşullarda karşılaştırılmıştır. Proteinaz enzim aktivitesinin belirlenmesinde sığır serum albumin ağar (pH 4.5) kullanılmıştır. Vajinitli 31 hastadan yedisi 1+ ve 24'ü 2+; taşıyıcı (kontrol) grubu 25 sustan 17'si 1+ ve sadece iki sus 2+ değerinde proteinaz enzim aktivitesi göstermiştir. Çalışmada hasta grubundan izole edilen suşlar taşıyıcı gruba oranla daha yüksek düzeyde proteinaz enzim aktivitesi göstermiş ve aradaki fark istatistiksel açıdan anlamlı bulunmuştur (p < 0.001). iki hasta grubundan elde edilen suşlar arasındaki proteinaz sekresyonu farkı, proteinaz yapımı ve C. albicans'ın neden olduğu vajinal kandidoz arasındaki karşılıklı ilişkiyi göstermektedir.

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Cite This Article

ERDENİZ, H., GÜRLER, B. (2022). Investigation of the correlation between proteinase activity of candida albicans strains and vulvovaginal candidosis. İnfeksiyon Dergisi, Cilt: 12 - Sayı: 3, 389–392. https://ajindex.com/articles/547015

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