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Journals / İnfeksiyon Dergisi / 2000 / Cilt: 14 - Sayı: 3

The presence of extended-spectrum beta-lactamase in Pseudomonas aeruginosa strains isolated from nosocomial infections

Nozokomiyal infeksiyonlu olgulardan izole edilen Pseudomonas aeruginosa suşlarında genişlemiş spektrumlu beta-laktamaz varlığı

Selim GÖRGÜN
Halil YAZGI
Selahattin ÇELEBİ
Cahit Bekir KAYHAN
Mustafa ERTEK
Pages
379–382
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All strains producing extended-spectrum beta-lactamase (ESBL) were sensitive to imipenem.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Treatment of nosocomial infections caused by resistant microorganisms carrying plasmids with multiple resistant genes are very difficult.
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Key Findings & Data:In seven species of 112 P. aeruginosa isolates a synergy was determined between ceftriaxon, ceftazidim, aztreonam and amoxicillin-clavulanic acid.
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Conclusion & Impact:All strains producing extended-spectrum beta-lactamase (ESBL) were sensitive to imipenem.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Treatment of nosocomial infections caused by resistant microorganisms carrying plasmids with multiple resistant genes are very difficult. In this study, the existence of extended spectrum beta-lactamase (ESBL) in Pseudomonas aeruginosa strains leading to nosocomial infections was investigated. The double disc synergistic method was used to observe synergistic effect. In seven species of 112 P. aeruginosa isolates a synergy was determined between ceftriaxon, ceftazidim, aztreonam and amoxicillin-clavulanic acid. All strains producing extended-spectrum beta-lactamase (ESBL) were sensitive to imipenem.

Özet

Çoklu direnç genleri taşıyan plazmitler aracılığıyla direnç kazanmış mikro-organizmaların neden olduğu hastane infeksiyonlarının tedavisi zordur. Bu çalışmada, Pseudomonas aeruginosa'nın neden olduğu hastane kaynaklı infeksiyoniardaki genişlemiş spektrumlu beta-laktamaz (ESBL) varlığı araştırılmıştır. Sineriistik etkiyi göstermek için çift disk sinerji yöntemi kullanılmıştır, izole edilen 112 P.aeruginosa suşundan yedisinde seftriakson, seftazidim ve aztreonam ile amoksisilin-klavulanik asit arasında sinerji saptanmış; ESBL sentezleyen suşların tamamı imipenem'e duyarlı bulunmuştur.

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Cite This Article

GÖRGÜN, S., YAZGI, H., ÇELEBİ, S., KAYHAN, C. B., ERTEK, M. (2022). The presence of extended-spectrum beta-lactamase in Pseudomonas aeruginosa strains isolated from nosocomial infections. İnfeksiyon Dergisi, Cilt: 14 - Sayı: 3, 379–382. https://ajindex.com/articles/546852

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