Journals / İnfeksiyon Dergisi / 2006 / Cilt: 20 - Sayı: 2

Clinical and radiological findings in a case of Varicella encephalitis

Bir Varicella ensefaliti olgusunda klinik ve radyolojik bulgular

Pages
131–135
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, the clinical and radiological findings of the case are discussed in the light of the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The Varicella-Zoster virus infection (chicken pox) is rarely seen in adults and subjects with normal immunity, but its complications might be fatal.
📊
Key Findings & Data:A 29-year-old previously healthy male patient applied to the emergency ward five days after the occurrence of chicken pox rashes with complaints of vertigo, nausea, and imbalance.
💡
Conclusion & Impact:In this article, the clinical and radiological findings of the case are discussed in the light of the literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The Varicella-Zoster virus infection (chicken pox) is rarely seen in adults and subjects with normal immunity, but its complications might be fatal. A 29-year-old previously healthy male patient applied to the emergency ward five days after the occurrence of chicken pox rashes with complaints of vertigo, nausea, and imbalance. Although Varicella-Zoster antibodies were found to be negative in the initial cerebrospinal fluid (CSF) and blood examinations of the patient, these antibodies were detected both in the CSF and blood of the patient on the tenth day. Right cerebellar and bilateral cerebellar hypoperfusion were determined with brain single photon emission tomography (SPECT) labelled with Tc-99m hexamethyl propylene amine oxime (HMPAO) whereas no pathologies were detected in the contrasted cranial magnetic resonance imaging (MRI). Partial clinical improvement was achieved after a 10-day antiviral therapy and an almost complete improvement was observed in the neurological examination of the patient at the third month follow up. Although the repeated cranial MRI examination performed in this period was found to be normal, in the Tc-99 HMPOA brain SPECT examination it was observed that the previously determined pathology continued to exist. In this article, the clinical and radiological findings of the case are discussed in the light of the literature.

Özet

Varicella-Zoster virus infeksiyonları (suçiçeği) erişkinlerde ve immünitesi sağlam olgularda nadir olup komplikasyonları fatal seyredebilmektedir. Daha öncesinde sağlıklı olan 29 yaşındaki erkek hasta, suçiçeği döküntülerinden beş gün sonra baş dönmesi, bulantı ve dengesizlik yakınması ile acil servise getirilmiştir. Hastanın yapılan ilk beyin-omurilik sıvısı (BOS) ve kan incelemelerinde Varicella-Zoster antikorları negatif bulunmasına karşılık onuncu günde yapılan incelemelerde hem kan hem BOS'ta antikorlar pozitif olarak saptanmıştır. Kontrastlı kraniyal manyetik rezonans görüntüleme (MRG)' sinde patoloji saptanmayan hastanın Technetium-99m-hegzametilpropilenaminoksim (Tc-99m-HMPAO) ile işaretli beyin tek foton emisyon bilgisayarlı tomografi (single photon emission computed tomography: SPECT) incelemesinde; sağ serebral ve iki yanlı serebellar hipoperfüzyon saptanmıştır. On günlük antiviral tedavi sonrası kısmi klinik düzelme sağlanan hastanın, üç ay sonraki kontrolünde nörolojik muayenesindeki patolojilerde tama yakın düzelme saptanmıştır. Bu dönemde tekrarlanan kraniyal MRG incelemesi normal olarak bulunmasına karşın Tc-99m HMPOA Beyin SPECT incelemesinde daha önceden saptanan patolojinin devam ettiği görülmüştür. Bu yazıda, olgunun klinik ve radyolojik bulguları literatür bilgileri ışığında tartışılmıştır.

🔖

Cite This Article

ŞAHİN, Ş., KARŞIDAĞ, S., ARISOY, S. A., TOPKAYA, E. A. (2022). Clinical and radiological findings in a case of Varicella encephalitis. İnfeksiyon Dergisi, Cilt: 20 - Sayı: 2, 131–135. https://ajindex.com/articles/546451

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Cepelowicz J, Allan R, Tunkel AR. Viral encephalitis. Curr Treat Options Infect Dis 2003; 5: 11-19
  2. Nussinovotch M, Soen G, Volovitz B, Versano I. Acute cerebellar ataxia associated with varicella. J Fam Pract 1995; 40: 494-6
  3. Kleinschmidt-DeMasters BK, Güden DH. The expanding spectrum of herpes virus infections of the nervous system. Brain Pathol 2001; 11: 440-51
  4. Sevim S, Doğu O, Ersöz G, Karakelle A. Varicella cerebellitis: Case report. Mersin Üniversitesi Tıp Fakültesi Dergisi 2002; 2: 264-6
  5. Whitley RJ. Varicella-Zoster Virus. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone, 2000: 1580-6
  6. Ametani M, Ogawa T, Tanabe Y, et al. Sequential MR imaging and SPECT studies in herpes simplex encephalitis with crossed cerebeliar hyperperfusion. Ann Nucl Med 2005; 19: 151-5
  7. Kao CH, Wang SJ, Mak SC, et al. Viral encephalitis in children: detection with technetium-99m HMPAO brain single-photon emission CT and its value in prediction of outcome. Am J Neuroradiol 1994; 15: 1369-73
  8. Launes J, Siren J, Valanne L, et al. Unilateral hyperfusion in brain-perfusion SPECT predicts poor prognosis in acute encephalitis. J Neurol 1992; 48:1347-51.