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Journals / İnfeksiyon Dergisi / 2004 / Cilt: 18 - Sayı: 4

Quinolone and trimethoprim-sulfamethoxazole susceptibility of Stenotrophomonas maltophilia strains

Stenotrophomonas maltophilia suşlarında kinolon ve trimetoprim-sulfametoksazol duyarlılığı

Hande ARSLAN
Kuru Emine İNCİ
Kurt Özlem AZAP
Özbalıkçı Sedef KARAMAN
Göknur YAPAR
Funda TİMURKAYNAK
Pages
463–466
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Because there are significant differences in the susceptibility patterns between centers and members of the floroquinolones, every center should study the antimicrobial susceptibility of their own for guidance in the empiric treatment of S. maltophilia infections.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Stenotrophomonas maltophilia has emerged as a significant pathogen in compromised patients, causing infections difficult to treat.
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Key Findings & Data:In this study, 29 isolates of S. maltophilia were tested against trimethoprim sulfamethoxazole (TMP-SMX), ciprofloxacin, ofloxacin and levofloxacin by agar dilution method.
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Conclusion & Impact:Because there are significant differences in the susceptibility patterns between centers and members of the floroquinolones, every center should study the antimicrobial susceptibility of their own for guidance in the empiric treatment of S. maltophilia infections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Stenotrophomonas maltophilia has emerged as a significant pathogen in compromised patients, causing infections difficult to treat. The purpose of this study was to determine the susceptibility of S. maltophilia to some antimicrobials. In this study, 29 isolates of S. maltophilia were tested against trimethoprim sulfamethoxazole (TMP-SMX), ciprofloxacin, ofloxacin and levofloxacin by agar dilution method. Amongst the 29 isolates tested 28 were sensitive to ofloxacin, 28 were sensitive to TMP-SMX, 24 were sensitive to levofloxacin and 3 were sensitive to ciprofloxacin-. Because there are significant differences in the susceptibility patterns between centers and members of the floroquinolones, every center should study the antimicrobial susceptibility of their own for guidance in the empiric treatment of S. maltophilia infections.

Özet

Stenotrophomonas maltophilia genel durumu düşkün hastalarda sınırlı tedavi seçenekleri olan infeksiyonlara yol açan bir patojendir. Bu çalışmanın amacı, S. maltophilia'mn bazı antimikrobiyallere duyarlılığını saptamak idi. Toplam 29 S. maltophilia susunun trimetoprim-sulfametoksazol (TMP-SMZ) ve bazı florokinolonlara (siprofloksasin, ofloksasin, levofloksasin) karşı duyarlılığı agar dilüsyon yöntemi ile araştırıldı. Suşların 28'i TMP-SMZ'ye duyarlı bulunurken florokinolon duyarlılığı sırasıyla ofloksasin için 28/29, levofloksasin için 24/29, siprofloksasin için 3/29 olarak bulundu. Stenotrophomonas maltophilia suşları için belirlenen antimikrobiyal duyarlılık oranlarının florokinolon grubunun üyeleri arasında belirgin farklılıklar göstermesi nedeniyle bu grubu tedavi alternatifi olarak düşünen her merkezin kendi duyarlılık oranlarını belirlemesi empirik tedavide yol gösterici olacaktır.

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Cite This Article

ARSLAN, H., İNCİ, K. E., AZAP, K. Ö., KARAMAN, Ö. S., YAPAR, G., TİMURKAYNAK, F. (2022). Quinolone and trimethoprim-sulfamethoxazole susceptibility of Stenotrophomonas maltophilia strains. İnfeksiyon Dergisi, Cilt: 18 - Sayı: 4, 463–466. https://ajindex.com/articles/545993

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References (12)

  1. Gales AC, Jones RN, Forward KR, Lifiares J, Sader HS, Verhoef J. Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999). Clin Infect Dis 2001; 32 (Suppl 2): 104-13
  2. Denton M, Kerr KG. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev 1998; 11: 57-80
  3. Valdezate S, Vindel A, Loza E, Baquero F, Canton R. Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains. Antimicrob Agents Chemother 2001; 45:1581-4
  4. Weiss K, Restieri C, Carolis ED, Laverdiere V, Guay H. Comparative activity of new quinolones against 326 clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother 2000; 45: 363-5
  5. Krueger TS, Clark E, Nix DE. In vitro susceptibility of Stenotrophomonas maltophilia to various antimicrobial combinations. Diagn Microbiol Infect Dis 2001; 41: 71 -8
  6. Vartivarian S, Anaissie E. Stenotrophomonas maltophilia and Burkolderia cepacia. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone, 2000: 2335-9
  7. Cohn ML, Waites KB. Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and time-kill studies. Antimicrob Agents Chemother 2001; 45:2126-8
  8. Hoban DJ, Bouchillon SK, Johnson LJ, et al. Comparative in vitro activity of gemifloxacin, ciprofloxacin, levofioxacin and ofloxacin in a North American surveillance study. Diagn Microbiol Infect Dis 2001; 40:51 -7
  9. Gesu GP, Marchetti F, Piccoli L, et al. Levofioxacin and ciproloxacin in vitro activities against 4003 clinical bacterial isolates collected in 24 Italian laboratories. Antimicrob Agents Chemother 2003; 47:816-9
  10. Hoban DJ, Bouchillon SK, Johnson JL, et al. Comparative in vitro potency of gemifloxacin and fluoroquinolones against recent European clinical isolates from a global surveillance study. Eur J Clin Microbiol Infect Dis 2001; 20: 814-9
  11. National Committee on Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing. Eleventh Informational Supplement Vol 21, No 1, January 2001
  12. Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Washington CW. Color Atlas and Textbook o