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Journals / IUFS Journal of Biology / 2010 / Cilt: 69 - Sayı: 1

Flavonoids and some biological activities of Ailanthus excelsa leaves

Khaled RASHED
Usama W. HAWAS
Siham El SHENAWY
Salwa M. NOFAL
Ataa SAİD
Pages
41–55
Publication Date
2022-10-18
DOI
—
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It was found that methanolic extract of Ailanthus excelsa leaves is nontoxic up to 5 g.kg-1 b. wt in mice.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the present study, the methanolic extract of Ailanthus excelsa (Roxb) leaves, a plant used in Egyptian traditional medicine was investigated for phytochemical constituents and some biological activities.
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Key Findings & Data:In vitro: antioxidant activity and in vivo: Lethal dose (LD50) acute and chronic toxicity and anti-nociceptive and antiinflammatory effects were determined.
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Conclusion & Impact:It was found that methanolic extract of Ailanthus excelsa leaves is nontoxic up to 5 g.kg-1 b. wt in mice.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the present study, the methanolic extract of Ailanthus excelsa (Roxb) leaves, a plant used in Egyptian traditional medicine was investigated for phytochemical constituents and some biological activities. In vitro: antioxidant activity and in vivo: Lethal dose (LD50) acute and chronic toxicity and anti-nociceptive and antiinflammatory effects were determined. It was found that methanolic extract of Ailanthus excelsa leaves is nontoxic up to 5 g.kg-1 b. wt in mice. Also rats were given a daily single oral dose of the extract for 7 and 30 successive days for assessment of acute and chronic toxicity. The extract did not induce any significant change in serum levels of ALT, AST, GGT, total protein, albumin, BUN and creatinine as compared with saline control group in rats. The extract exhibited a significant antioxidant, anti-nociceptive activity and no antiinflammatory effects. Chromatographic separation of A. excelsa MeOH extract has yielded eleven known flavonoid compounds. Their structures were established on the basis of chromatographic properties and spectroscopic (UV, 1H, 13C NMR, MS) analyses.

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Cite This Article

RASHED, K., HAWAS, U. W., SHENAWY, S. E., NOFAL, S. M., SAİD, A. (2022). Flavonoids and some biological activities of Ailanthus excelsa leaves. IUFS Journal of Biology, Cilt: 69 - Sayı: 1, 41–55. https://ajindex.com/articles/544051

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