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Journals / IUFS Journal of Biology / 2012 / Cilt: 71 - Sayı: 2

Sıçanlarda sisplatin içeren kemoterapi rejimlerinin nefrotoksisitesi üzerine Ginkgo biloba nın etkileri

The effects of Ginkgo biloba on nephrotoxicity induced by cisplatin-based chemotherapy protocols in rats

OZAKPINAR BİNGÖL Özlem
Zeynep CIRAKLI
Philip Martin CLARK
Mesut SANCAR
Feriha ERCAN
Fikret Vehbi IZZETTIN
Zarife Nigar OZDEMİR
Pınar TURAN
Betül OKUYAN
Pages
103–111
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Ginkgo biloba extract significantly decreased the serum creatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also improved the depletion of kidney GSH levels in cisplatin administered rats (p

📌 3 Key Takeaways

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Objective & Hypothesis:The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity induced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats.
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Key Findings & Data:The animals were randomly divided into eight groups each consisting of six rats.
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Conclusion & Impact:Ginkgo biloba extract significantly decreased the serum creatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also improved the depletion of kidney GSH levels in cisplatin administered rats (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity induced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats. The animals were randomly divided into eight groups each consisting of six rats. Serum blood urea nitrogen (BUN) and creatinine values at baseline and after drug administration, kidney malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase activity (MPO) were measured, and a histopathologic examination of kidney tissues was carried out. Ginkgo biloba extract significantly decreased the serum creatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also improved the depletion of kidney GSH levels in cisplatin administered rats (p

Özet

Bu çalışmada, sıçanlarda sisplatin ve diğer kemoterapötik ajanların (etopozid ve gemsitabiıı) nefrotoksisitesi üzerine Ginkgo biloba'ntn olası etkilerinin belirlenmesi amaçlandı. Hayvanlar, rastgele olarak ve her biri 6 adet sıçandan oluşan 10 gruba ayrıldı. Deneyin başlangıcında ve tedavi sonrasında serum BUN (kan üre azotu) ve kreatinin değerleri; tedavi sonrasında böbrek dokusu malondialdehit (MDA) seviyeleri ile glutatyon (GSH) ve miyeloperoksidaz (MPO) aktiviteleri ölçüldü. Ayrıca böbrek dokusunun histopatolojik incelemesi yapıldı. Ginkgo biloba ekstresi, sisplatin tedavisinin bir sonucu olarak yükselmiş olan serum kreatinin ve böbrek MDA seviyelerini anlamlı olarak düşürdü (p

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Cite This Article

Özlem, O. B., CIRAKLI, Z., CLARK, P. M., SANCAR, M., ERCAN, F., IZZETTIN, F. V., OZDEMİR, Z. N., TURAN, P., OKUYAN, B. (2022). Sıçanlarda sisplatin içeren kemoterapi rejimlerinin nefrotoksisitesi üzerine Ginkgo biloba nın etkileri. IUFS Journal of Biology, Cilt: 71 - Sayı: 2, 103–111. https://ajindex.com/articles/544025

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