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Journals / IUFS Journal of Biology / 2014 / Cilt: 73 - Sayı: 2

Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri

Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds

Emine Yıldız TURHAN
Özlem SAÇAN
Pages
47–52
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results obtained in the present study indicate that plant extracts and chemical compounds examined can be a potential source of novel antiinflammatory therapeutics.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. 1.13.11.12) are a family of non-heme ironcontaining dioxygenases.
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Key Findings & Data:In this study, the inhibitory effects of ethanolic extracts prepared from 12 different plants and 12 different chemical compounds were investigated on the activity of LOX which has an important value in the health area.
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Conclusion & Impact:The results obtained in the present study indicate that plant extracts and chemical compounds examined can be a potential source of novel antiinflammatory therapeutics.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. 1.13.11.12) are a family of non-heme ironcontaining dioxygenases. LOXs are associated with several inflammation-related diseases such as arthritis, asthma, cardiovascular, kidney, skin and allergic diseases, neurodegenerative disorders, cancer and metabolic syndrome. In this study, the inhibitory effects of ethanolic extracts prepared from 12 different plants and 12 different chemical compounds were investigated on the activity of LOX which has an important value in the health area. All the plant extracts and chemical substances used in our study showed LOX inhibitory effect. The enzyme inhibitory activities of the extracts and chemical compounds were increasing in a dose-dependent manner. The results obtained in the present study indicate that plant extracts and chemical compounds examined can be a potential source of novel antiinflammatory therapeutics.

Özet

Lipoksijenazlar (LOXs, linoleat: oksijen redüktaz, E.C.1.13.11.12) hem içermeyen, demir içeren dioksijenaz ailesidir. Lipoksijenazlar, artrit, astım, kalp damar, böbrek, deri ve alerjik hastalıklar, nörodejeneratif hastalıklar, kanser ve metabolik sendrom gibi çeşitli inflamasyon ile ilişkili hastalıklar ile ilgilidir. Bu çalışmada, farklı bitkilerden hazırlanan etanollü ekstrelerin ve bazı kimyasal bileşiklerin sağlık alanında önemli bir alana sahip olan LOX aktivitesi üzerine inhibe edici etkileri incelenmiştir. Çalışmada kullanılan tüm bitki ekstreleri ve kimyasal maddelerin LOX inhibitör etkisine sahip olduğu belirlenmiştir. Bitki ekstreleri ve kimyasal bileşiklerin enzim inhibitör aktiviteleri, doza bağlı olarak artmaktadır. Bu çalışmadan elde edilen sonuçlara göre, incelenen bitki ekstreleri ve bazı kimyasal bileşikler antiinflamatuar tedavide yeni bir potansiyel kaynak olabilirler.

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Cite This Article

TURHAN, E. Y., SAÇAN, Ö. (2022). Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri. IUFS Journal of Biology, Cilt: 73 - Sayı: 2, 47–52. https://ajindex.com/articles/543999

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