AI Summary & Key Takeaways
AI InsightIn conclusion, exposure to β-CF resulted in increased oxidative damage and has been found to cause neurotoxicity even at low concentrations.
📌 3 Key Takeaways
Abstract
In this study, some biochemical responses of Beta-Cyfluthrin (β-CF), which is a commercial insecticide in Dreissena polymorpha, were investigated. The 96 hour LC50 value of β-CF on D. polymorpha was calculated as 509.62 µg L-1. D. polymorpha was exposed to subletal concentrations (1/16, 1/8 and 1/4 of LC50 value: 32, 64 and 128 µg L-1) of β-CF for 24 and 96 hours. Malondialdehyde (MDA) and reduced glutathione (GSH) levels and Acetylcholinesterase (AChE) enzyme activities were determined in D. polymorpha individuals. In D. polymorpha exposed to β-CF, MDA levels increased compared to control and with increasing concentration. It was determined that GSH level decreased and AChE activity was inhibited compared to control and with increasing concentration. In conclusion, exposure to β-CF resulted in increased oxidative damage and has been found to cause neurotoxicity even at low concentrations.
Özet
Yapılan bu çalışmada, Dreissena polymorpha’da ticari insektisit olan Beta-Cyfluthrin (β-CF)’nin bazı biyokimyasal yanıtları araştırılmıştır. β-CF’nin D. polymorpha üzerindeki 96 saatlik LC50 değeri 509.62 µg L-1 olarak hesaplanmıştır. D. polymorpha, β-CF’nin subletal konsantrasyonlar (LC50 değerinin 1/16, 1/8 ve1/4’ü:32, 64 ve 128 µg L-1)’ına 24 ve 96 saat süre ile maruz bırakılmıştır. D. polymorpha bireylerinde malondialdehit (MDA) ve redükte glutatyon (GSH) düzeyleri ile Asetilkolinesteraz (AChE) enzim aktiviteleri belirlenmiştir. β-CF’ye maruz bırakılan D. polymorpha’da, MDA seviyeleri kontrole kıyasla ve artan konsantrasyonla artmıştır. Kontrole kıyasla ve artan konsantrasyonla GSH seviyesinin azaldığı ve AChE aktivitesi inhibe olduğu belirlenmiştir. Sonuç olarak, β-CF'ye maruz kalan D. polymorpha bireylerinde oksidatif hasarda artışa, düşük konsantrasyonlarda bile nörotoksisiteye neden olduğu bulunmuştur.