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Journals / International Journal of Medical Biochemistry / 2022 / Cilt: 5 - Sayı: 1

Ischemia modified albumin level and thiol/disulfide homeostasis in the etiology of tinnitus

Salim NEŞELİOĞLU
Huseyin KURKU
Mehmet Akif BOR
Mustafa Faris TULGAR
Necati ALATAŞ
Pages
28–33
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In the present study, in the tinnitus group, higher values of IMA and IMA/AlbR, which are markers of ischemic status, support the theory specifying that ischemia has an influential role in the etiology of tinnitus

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Although many theories about the etiology of tinnitus have been proposed, it has not been fully clarified.In this study, we investigated the role of ischemia in the etiology of tinnitus.
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Key Findings & Data:Methods: A total of 90 participants, 50 tinnitus patients and 40 controls, were included in this study.
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Conclusion & Impact:Conclusion: In the present study, in the tinnitus group, higher values of IMA and IMA/AlbR, which are markers of ischemic status, support the theory specifying that ischemia has an influential role in the etiology of tinnitus
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Although many theories about the etiology of tinnitus have been proposed, it has not been fully clarified.In this study, we investigated the role of ischemia in the etiology of tinnitus. Methods: A total of 90 participants, 50 tinnitus patients and 40 controls, were included in this study. Total thiol (TT),native thiol (NT), NT/TT ratio, disulfide, disulfide/TT ratio, disulfide/NT ratio, ischemia-modified albumin (IMA), and IMA/albumin ratio (IMA/AlbR) values of tinnitus patient group and controls were compared and receiver operating characteristic (ROC) analyses conducted. Results: IMA (0.767±0.06) and IMA/AlbR (17.71±2.46) values were statistically significantly higher in the tinnitus group than in the control group (0.742±0.06 vs. 16.00±2.48 and p=0.040 vs. p=0.002, Independent Samples test). No statistically significant difference was observed between the groups for the other parameters. While albumin was presenting a perfect positive correlation with TT and NT, IMA showed rugged negative parallelism with NT and TT, similar to that ofIMA/AlbR. According to ROC analysis, a cut-off value of 14.29 was found to be statistically significant for IMA/AlbR in distinguishingpatients with tinnitus from the controls (sensitivity of 96%, specificity of 32.5%, AUC: 0.676, and p=0.002). Conclusion: In the present study, in the tinnitus group, higher values of IMA and IMA/AlbR, which are markers of ischemic status, support the theory specifying that ischemia has an influential role in the etiology of tinnitus

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Cite This Article

NEŞELİOĞLU, S., KURKU, H., BOR, M. A., TULGAR, M. F., ALATAŞ, N. (2022). Ischemia modified albumin level and thiol/disulfide homeostasis in the etiology of tinnitus. International Journal of Medical Biochemistry, Cilt: 5 - Sayı: 1, 28–33. https://ajindex.com/articles/541389

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