AI Summary & Key Takeaways
AI InsightMore comprehensive studies are recommended to understand the tissue healing process after implant treatment.
📌 3 Key Takeaways
Abstract
Aim: The aim of this study was to determine the levels of biochemical markers detected in the peri-implant crevicular fluid (PICF) before and 6 months after loading in completely edentulous patients with two implantsupported mandibular overdentures and to correlate them with clinical parameters. Methodology: Two implants were applied to the mandibular canine region of the 20 completely edentulous and systemically healthy patients (11 females, 9 males) with conventional 2-stage surgery. PICF samples of the participants were collected before and 6 months after prosthetic loading, and clinical parameters—including modified plaque index (MPI), gingival index (GI), bleeding on probing (BoP), probing pocket depth (PPD), and keratinized gingival width (KGW)—were recorded. Interleukin-1β (IL1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-8 (MMP-8), and aspartate aminotransferase (AST) levels were examined in PICF samples via enzyme-linked immunosorbent assay (ELISA). Results: The average age of the participants was 57.05 ± 9.82 years. Although a decrease was observed in all clinical parameters after prosthetic loading compared to baseline levels, this decrease was not considered statistically significant (p>0.05). PICF volume showed a statistically significant decrease from baseline to 6 months (p0.05). Conclusion: Within the limits of this study, the PICF marker levels and clinical parameters determined following osseointegration and 6 months after prosthetic loading are similar. This suggests that the studied sample has prosthetic restorations that contribute positively to the tissue maturation process and apply ideal forces to the tissue. More comprehensive studies are recommended to understand the tissue healing process after implant treatment.