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Journals / Infectious diseases and clinical microbiology (Online) / 2022 / Cilt: 4 - Sayı: 1

Intrathecal Colistin Induced Chemical Meningitis in a Case of Multi-drug Resistant Acinetobacter baumannii Meningitis

Serap ŞİMŞEK YAVUZ
Aysun BENLİ
Haluk ERAKSOY
Pages
76–80
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Discontinuation of intrathecal therapy or reducing the antibiotic dose will be the most appropriate approach to manage such cases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The possibility of encountering multi-drug resistant Gram-negative bacteria is higher in nosocomial meningitis.
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Key Findings & Data:These bacteria are clinically important because of their higher mortality rate, and colistin is almost the only treatment option in resistant strains.
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Conclusion & Impact:Discontinuation of intrathecal therapy or reducing the antibiotic dose will be the most appropriate approach to manage such cases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The possibility of encountering multi-drug resistant Gram-negative bacteria is higher in nosocomial meningitis. These bacteria are clinically important because of their higher mortality rate, and colistin is almost the only treatment option in resistant strains. However, intrathecal administration of colistin can result in chemical meningitis. We reported a case with chemical meningitis during the intravenous sulbactam plus colistin and intrathecal colistin therapy for multi-drug resistant Acinetobacter baumannii meningitis. Cerebrospinal fluid findings of the patient improved after discontinuation of intrathecal colistin therapy. This reversible complication may occur during intrathecal therapy. Discontinuation of intrathecal therapy or reducing the antibiotic dose will be the most appropriate approach to manage such cases.

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Cite This Article

YAVUZ, S. Ş., BENLİ, A., ERAKSOY, H. (2022). Intrathecal Colistin Induced Chemical Meningitis in a Case of Multi-drug Resistant Acinetobacter baumannii Meningitis. Infectious diseases and clinical microbiology (Online), Cilt: 4 - Sayı: 1, 76–80. https://ajindex.com/articles/539062

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