Journals / Infectious diseases and clinical microbiology (Online) / 2022 / Cilt: 4 - Sayı: 1

Retrospective Evaluation of Risk Factors for Invasive Candida Infections in a Medical Intensive Care Unit

Pages
62–71
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When patients with and without fungal growth were compared, a significant difference was found between groups in terms of age, acute physiology and chronic health evaluation II (APACHE II) score, length of ICU and hospital stay, ICU and hospital mortality (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We aimed to detect the risk factors for invasive candida infections by evaluating the fungal strains cultivated from samples taken in a medical intensive care unit (ICU).
📊
Key Findings & Data:Materials and Methods: We investigated fungal growths between January 1, 2016, and December 1, 2018, retrospectively.
💡
Conclusion & Impact:When patients with and without fungal growth were compared, a significant difference was found between groups in terms of age, acute physiology and chronic health evaluation II (APACHE II) score, length of ICU and hospital stay, ICU and hospital mortality (p
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to detect the risk factors for invasive candida infections by evaluating the fungal strains cultivated from samples taken in a medical intensive care unit (ICU). Materials and Methods: We investigated fungal growths between January 1, 2016, and December 1, 2018, retrospectively. All reported fungal growths and demographic characteristics, clinical features, treatments and outcomes of the patients with fungal growths were recorded. Results: Fungal growths were reported from 384 different samples obtained from 179 ICU patients. The most common strain was determined to be C. albicans (47.9%). The incidence of non-albicans Candida strains was increased over the years (2016 - 44%, 2017 - 52.5%, 2018 - 49%), most significantly C. glabrata (7.7% to 14.6%). The most common strain was C. parapsilosis (57.9%) in patients with candidemia, and infection was more severe among them. Fluconazole resistance was rare. When patients with and without fungal growth were compared, a significant difference was found between groups in terms of age, acute physiology and chronic health evaluation II (APACHE II) score, length of ICU and hospital stay, ICU and hospital mortality (p

🔖

Cite This Article

BİLGİN, M. K., TALAN, L., EVREN, E., ALTINTAŞ, N. D. (2022). Retrospective Evaluation of Risk Factors for Invasive Candida Infections in a Medical Intensive Care Unit. Infectious diseases and clinical microbiology (Online), Cilt: 4 - Sayı: 1, 62–71. https://ajindex.com/articles/539048

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. 1 Paiva JA, Pereira JM, Tabah A, Mikstacki A, de Carvalho FB, Koulenti D et al. Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: Data from the EUROBACT study. Crit Care. 2016
  2. [CrossRef] 2 Calandra T, Roberts JA, Antonelli M, Bassetti M, Vincent JL. Diagnosis and management of invasive candidiasis in the ICU: An updated approach to an old enemy. Crit Care. 2016
  3. [CrossRef] 3 Taccone FS, Van den Abeele AM, Bulpa P, Misset B, Meersseman W, Cardoso T, et al. Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. Crit Care. 2015
  4. [CrossRef] 4 Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016
  5. e1-50. [CrossRef] 5 Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G. Invasive fungal infections in the ICU: How to approach, how to treat. Molecules 2014
  6. [CrossRef] 6 Matthaiou DK, Christodoulopoulou T, Dimopoulos G. How to treat fungal infections in ICU patients. BMC Infect Dis. 2015
  7. [CrossRef] 7 Singh T, Kashyap AK, Ahluwalia G, Chinna D, Sidhu SS. Epidemiology of fungal infections in critical care setting of a tertiary care teaching hospital in North India: A prospective surveillance study. J Clin Sci Res. 2014
  8. 8 Yapar N. Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag. 2014
  9. [CrossRef] 9 Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007
  10. [CrossRef] 10 Davis SL, Vazquez JA, McKinnon PS. Epidemiology, risk factors, and outcomes of Candida albicans versus non-albicans candidemia in nonneutropenic patients. Ann Pharmacother. 2007
  11. [CrossRef] 11 Sandhu R, Dahiya S, Sayal P, Budhani D. Increased role of non-albicans Candida, potential risk factors, and attributable mortality in hospitalized patients. J Health Res Rev. 2017
  12. [CrossRef] 12 León C, Alvarez-Lerma F, Ruiz-Santana S, León MA, Nolla J, Jordá R, et al. Fungal colonization and/or infection in non-neutropenic critically ill patients: Results of the EPCAN observational study. Eur