AI Summary & Key Takeaways
AI InsightThis phenolic compound was tested for the inhibition of CA I, CA II, AChE, and 𝛼-glycosidase enzymes and demonstrated efficient inhibition profiles with Ki value of 31.89 ± 9.07 nM for CA I, 49.25 ± 12.85 nM for CA II, 184.67 ± 30.37 nM for AChE, and 16.99 ± 4.40 nM for 𝛼-glycosidase, respectively.
📌 3 Key Takeaways
Abstract
Bioactive flavonoids are considered to be the most important phytochemicals in food that provide many biological benefits for human beings. They have many pharmacological activities that include antioxidant, anti-bacterial, anti-cholinergic, anti-diabetic, anti-mutagenic and antiinflammatory properties. Morin, a member of flavonoids, exhibit many therapeutic properties by interacting with nucleic acids, enzymes and protein. In this study, morin as natural a phenolic compound showed inhibitory effects against human carbonic anhydrase (CA) isoforms I and II (CA I and II), acetylcholinesterase (AChE) and 𝛼-glycosidase enzymes. This phenolic compound was tested for the inhibition of CA I, CA II, AChE, and 𝛼-glycosidase enzymes and demonstrated efficient inhibition profiles with Ki value of 31.89 ± 9.07 nM for CA I, 49.25 ± 12.85 nM for CA II, 184.67 ± 30.37 nM for AChE, and 16.99 ± 4.40 nM for 𝛼-glycosidase, respectively.
Özet
Biyoaktif flavonoidler, insan için birçok biyolojik faydalar sağlayan gıdadaki en önemlifitokimyasallar olarak kabul edilir. Antioksidan, anti-bakteriyel, anti-kolinerjik, anti-diyabetik, antimutajenik ve anti-enflamatuar özellikler gibi birçok farmakolojik aktiviteye sahiptirler. Flavonoidlerinbir üyesi olan morin, nükleik asitler, enzimler ve proteinler ile etkileĢime girerek birçok terapötiközellik sergiler. Bu çalıĢmada, doğal fenolik bir bileĢik olarak morin, insan karbonik anhidraz (CA)izoformları I ve II (CA I ve II), asetilkolinesteraz (AChE) ve 𝛼-glikozidaz enzimlerine karĢı inhibeedici etkiler göstermiĢtir. Bu fenolik bileĢik, CA I, CA II, AChE ve 𝛼-glikozidaz enzimlerinininhibisyonu için test edildi ve sırasıyla CA I için 31.89 ± 9.07 nM, CA II için 49.25 ± 12.85 nM, AChEiçin 184.67 ± 30.37 nM ve 𝛼-glikozidaz için 16.99 ± 4.40 nM Ki değerleri ile etkili inhibisyonprofilleri gösterdi.