SavedAdd your journal

Journals / Haydarpaşa Numune Medical Journal / 2021 / Cilt: 61 - Sayı: 4

Diagnostic Value of Serum Procalcitonin and C-reactive Protein Levels in Neonatal Sepsis

Murat ELEVLİ
Emel ATAOĞLU
Derya BÜYÜKKAYHAN
Mehmet ERCEYLAN
Pages
392–396
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Pre-treatment PCT and CRP values of the study group were significantly higher than the control group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Rapid and early diagnosis in neonatal sepsis is of great importance in reducing morbidity and mortality.
📊
Key Findings & Data:An increase in acute phase reactants before the causative agent is shown in the hemoculture supports the diagnosis.
💡
Conclusion & Impact:Results: Pre-treatment PCT and CRP values of the study group were significantly higher than the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Rapid and early diagnosis in neonatal sepsis is of great importance in reducing morbidity and mortality. An increase in acute phase reactants before the causative agent is shown in the hemoculture supports the diagnosis. Monitoring of C-reactive protein (CRP) levels is used for this purpose in clinical applications. In recent years, the use of procalcitonin (PCT) in neonatal sepsis has come to the fore. PCT increase occurs earlier than CRP. In this study, we aimed to compare CRP and PCT levels in the diagnosis and follow-up of neonatal sepsis. Methods: The study was carried out with 40 patients hospitalized in the neonatal intensive care unit (NICU) with the diagnosis of sepsis and 40 control subjects. Results: Pre-treatment PCT and CRP values of the study group were significantly higher than the control group (p

🔖

Cite This Article

ELEVLİ, M., ATAOĞLU, E., BÜYÜKKAYHAN, D., ERCEYLAN, M. (2022). Diagnostic Value of Serum Procalcitonin and C-reactive Protein Levels in Neonatal Sepsis. Haydarpaşa Numune Medical Journal, Cilt: 61 - Sayı: 4, 392–396. https://ajindex.com/articles/535920

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Polin RA, Paraviccini E, Regan JA, Taeusch HW. Bacterial sepsis and meningitis. In: Taeusch HW, Ballard RA, Gleason CA (editors). Avery’s Diseases of the Newborn. 8th ed. Philadelphia: Elsevier Inc., 2005: 551–7
  2. Chiesa C, Panero A, Osborn JF, Simonetti AF, Pacifico L. Diagnosis of neonatal sepsis: a clinical and laboratory challenge. Clin Chem.2004;50:279–87
  3. Edwards MS, Baker CJ. Sepsis in the Newborn. In: Gershon AA, Hotez PJ, Katz SL (editors). Krugman’s ınfectious diseases of children. 11th ed. Philadelphia: Mosby, 2004: 545-61
  4. Du Clos TW. Function of C-reactive protein. Ann Med 2000;32:274–8
  5. Benitz WE, Han MY, Madan A, Ramachandra P. Serial serum Creactive protein levels in the diagnosis of neonatal infection. Pediatrics 1998;102:E41
  6. Gerdes JS. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin North Am 2004;51:939–59, viii-ix
  7. Mehr S, Doyle LW. Cytokines as markers of bacterial sepsis in newborn infants: a review. Pediatr Infect Dis J 2000;19:879–87
  8. Carrol ED, Thomson AP, Hart CA. Procalcitonin as a marker of sepsis. Int J Antimicrob Agents 2002;20:1–9
  9. Gendrel D, Raymond J, Coste J, Moulin F, Lorrot M, Guérin S, et al. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr Infect Dis J 1999;18:875–81
  10. Van der Kaay DC, De Kleijn ED, De Rijke YB, Hop WC, De Groot R, Hazelzet JA. Procalcitonin as a prognostic marker in meningococcal disease. Intensive Care Med 2002;28:1606– 12
  11. Yıldız C, Yıldız H, Kavuncuoğlu S, Şiraneci R. Procalcitonin levels in the diagnosis of early neonatal sepsis. Çocuk Sağlığı ve Hastalıkları Dergisi 2003;46:90–7
  12. Hatherill M, Tibby SM, Sykes K, Turner C, Murdoch IA. Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child 1999;81:417–21
  13. Linda L Belling, RN, NNP. Neonatal sepsis. Pediatr Neonatol 2006;26:1–27
  14. Bozkaya D, Yiğit Ş, Yurdakök M. Is serum procalcitonin level a reliable indicator in early diagnosis of congenital pneumonia? Turk J Pediatr 2019;61:34–9
  15. Canpolat FE, Yiğit S, Korkmaz A, Yurdakök M, Tekinalp G. Procalcitonin versus CRP as an early indicator of fetal infection in preterm premature rupture of membranes. Turk J Pediatr 2011;53:180–6
  16. Lencot S, Cabaret B, Sauvage G, Laurans C, Launay E, Orsonneau JL, et al. A new procalcitonin cord-based algorithm in early-onset neo