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Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 2

Evaluation of the Proliferation Markers in Interstitial Cystitis/Bladder Pain Syndrome: An Experimental Model

İnterstisyel Sistit/Mesane Ağrısı Sendromu Deneysel Modellerinde Proliferasyon Belirteçlerinin Değerlendirilmesi

Rashad SHOLAN
Pages
162–168
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was a strongcorrelation between these indicators in the urine of animals withIC/BPS created by a 70% alcohol solution (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study was to determine the level of nervegrowth factor (NGF) and epidermal growth factor (EGF) in ananimal model of interstitial cystitis/bladder pain syndrome (IC/BPS) and identify correlations between them.Methods: IC/BPS modeling was performed on white NewZealand female rabbits divided into six groups depending onthe methods of modeling.
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Key Findings & Data:The correlationbetween the indicators was calculated by the Pearson correlationcoefficient.Results: An increase in the concentration of NGF and EGF wasdetected in animals of all experimental groups; a significantlyhigh level of these factors in blood and urine was determinedin a toxic model created with the introduction of urine into thesubmucosal layer of the bladder wall.
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Conclusion & Impact:There was a strongcorrelation between these indicators in the urine of animals withIC/BPS created by a 70% alcohol solution (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to determine the level of nervegrowth factor (NGF) and epidermal growth factor (EGF) in ananimal model of interstitial cystitis/bladder pain syndrome (IC/BPS) and identify correlations between them.Methods: IC/BPS modeling was performed on white NewZealand female rabbits divided into six groups depending onthe methods of modeling. Urine and blood levels of NGF andEGF were determined by the ELISA method. The correlationbetween the indicators was calculated by the Pearson correlationcoefficient.Results: An increase in the concentration of NGF and EGF wasdetected in animals of all experimental groups; a significantlyhigh level of these factors in blood and urine was determinedin a toxic model created with the introduction of urine into thesubmucosal layer of the bladder wall. The correlation betweenNGF and EGF tended to increase by 14 days. There was a strongcorrelation between these indicators in the urine of animals withIC/BPS created by a 70% alcohol solution (p

Özet

Amaç: Bu çalışmanın amacı, interstisyel sistit/mesane ağrısı (IC/ BPS) sendromu deneysel modellerine sahip hayvanlarda sinir büyüme faktörü (NGF) ve epidermal büyüme faktörü (EGF) düzeylerini belirlemek ve aralarındaki ilişkileri tespit etmektir. Yöntemler: Modelleme yöntemlerine bağlı olarak altı gruba ayrılan beyaz Yeni Zelanda dişi tavşanlarında IC/BPS modellemesi yapıldı. Sinir büyüme faktörü ve epidermal büyüme faktörü ELISA yöntemi ile kanda ve idrarda belirlendi. Göstergeler arasındaki korelasyon Pearson katsayısı ile hesaplandı. Bulgular: Tüm deney gruplarındaki hayvanlarda sinir büyüme faktörü ve epidermal büyüme faktörü konsantrasyonunda bir artış tespit edildi; Kan ve idrarda bu faktörlerin anlamlı derecede yüksek olduğu, idrarın mesanenin submukoz tabakasına katılmasıyla toksik bir modelde tespit edildi. Sinir büyüme faktörü ve epidermal büyüme faktörü arasındaki korelasyon 14 gün artma eğilimindeydi. Bu göstergeler arasında hayvanların idrarında %70 alkol solüsyonunun oluşturduğu IC/BPS ile güçlü bir korelasyon vardı (p

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Cite This Article

SHOLAN, R. (2022). Evaluation of the Proliferation Markers in Interstitial Cystitis/Bladder Pain Syndrome: An Experimental Model. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 2, 162–168. https://ajindex.com/articles/535142

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