SavedAdd your journal

Journals / Haseki Tıp Bülteni / 2021 / Cilt: 59 - Sayı: 5

Antibody False Positivity Among COVID-19 Convalescent Plasma Donors: A Comparative Study from the Turkish Red Crescent Blood Center

Kerem KINIK
Fatma Meric YILMAZ
Aziz KARACA
Levent HAYAT
Can Murat BEKER
Nurettin HAFIZOĞLU
Pages
353–357
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Repeated reactivity rates (1.87%) were significantly higher than the control group (0.13%, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: During our routine work at the Turkish Red Crescent (TRC) laboratories, human immunodeficiency virus (HIV) 1/2 antibody false-positive results were observed among Coronavirus disease-2019 convalescent plasma (CP) donors more frequently than healthy donors.
📊
Key Findings & Data:We aimed to determine anti-HIV 1/2 antibody false-positivity rates among the CP donors and healthy blood donors.
💡
Conclusion & Impact:Results: Repeated reactivity rates (1.87%) were significantly higher than the control group (0.13%, p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: During our routine work at the Turkish Red Crescent (TRC) laboratories, human immunodeficiency virus (HIV) 1/2 antibody false-positive results were observed among Coronavirus disease-2019 convalescent plasma (CP) donors more frequently than healthy donors. We aimed to determine anti-HIV 1/2 antibody false-positivity rates among the CP donors and healthy blood donors. Methods: The present study was designed as a cross-sectional study which was a type of observational study. Total 3689 donations from 2593 donors donated CP to the TRC between 11 April-06 July 2020, were screened by electrochemiluminescence immunoassay for the presence of antibody against HIV ½. The confirmation tests were performed with line immunoassay. All of the donors were non-remunerated CP donors between the ages of 18-60. For the control group, 411078 donations from 407363 healthy blood donors were received on the same days. Results: Repeated reactivity rates (1.87%) were significantly higher than the control group (0.13%, p

🔖

Cite This Article

KINIK, K., YILMAZ, F. M., KARACA, A., HAYAT, L., BEKER, C. M., HAFIZOĞLU, N. (2022). Antibody False Positivity Among COVID-19 Convalescent Plasma Donors: A Comparative Study from the Turkish Red Crescent Blood Center. Haseki Tıp Bülteni, Cilt: 59 - Sayı: 5, 353–357. https://ajindex.com/articles/535134

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. World Health Organization (2020). Coronavirus disease (COVID-19) pandemic page [online]. Available from: https://www.who.int/emergencies/diseases/novelcoronavirus-2019. Accessed August 18, 2021
  2. World Health Organization (2020). Rolling updates on coronavirus disease (COVID-19). Available from: https://www. who.int/emergencies/diseases/novel-coronavirus-2019/ events-as-they-happen. Updated July 31, 2020. Accessed August 23, 2021
  3. Casadevall A, Scharff MD. Return to the past: the case for antibody-based therapies in infectious diseases. Clin Infect Dis 1995;21:150-61
  4. Stokes J, Jr, Wolman Ij, Carpenter Hc, Margoliıs J. Prophylactic Use of Parents' Whole Blood in Anterior Poliomyelitis: Philadelphia Epidemic Of 1932. Am J Dis Child 1935;50:581- 95. doi:10.1001/archpedi.1935.01970090011002 5. Hung IF, To KK, Lee CK, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clin Infect Dis 2011;52:447- 56
  5. Zhou B, Zhong N, Guan Y. Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med 2007;357:1450-1
  6. Zhang JS, Chen JT, Liu YX, et al. A serological survey on neutralizing antibody titer of SARS convalescent sera. J Med Virol 2005;77:147-50
  7. Ko JH, Seok H, Cho SY, et al. Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience. Antivir Ther 2018;23:617-22
  8. World Health Organisation. Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease (2014). Available from: https://www.who.int/csr/ resources/publications/ebola/convalescent-treatment/en/. Accessed August 25, 2021
  9. Xinhua. China puts 245 COVID-19 patients on convalescent plasma therapy available from: http://www.xinhuanet.com/ english/2020-02/28/c_138828177.htm. Accessed August 25, 2021
  10. CBER. Investigational COVID-19 Convalescent Plasma Emergency INDs. Avaliable from: https://www.fda.gov/ vaccines-blood-biologics/investigational-new-drug-ind-ordevice-exemption-ideprocess-cber/investigational-covid-19- convalescent-plasma-emergency-inds. Accessed March 24, 2020
  11. University of South Carolina. İmmunoloji – Bölüm Yedi İmmunoglobülin- Antijen-Antikor Reaksiyonlari ve Seçilmiş Testler (in Turkish) available from: https:// www.microbiologybook.org/Turkish-immunol/ immunolchapter7turk.htm. Accessed August 25, 2021
  12. Vlasova AN, Zhang X, Hasoksuz M, et al. Two-way antig