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Journals / Haseki Tıp Bülteni / 2019 / Cilt: 57 - Sayı: 1

Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits

Tavşanlarda Tirotoksikozun Safra Taşı Oluşumu Üzerine Etkilerinin Değerlendirilmesi

Nuri Aydın KAMA
Yusuf GÜNAY
Ayşe BİLGİHAN
Tanju TÜTÜNCÜ
Gülcan KORKMAZ
Tuba ÖCALAN
Pages
91–97
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Atthe end of seven weeks, all rabbits were sacrificed, blood was collectedfor analysis, and cholecystectomy was performed.Results: Serum levels of both free triiodothyronine (FT3) and thyroxine(FT4) were significantly higher in rabbits receiving thyroid hormone(p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The etiopathogenesis of gallstone formation is well known, butonly a few studies have investigated the effects of thyrotoxicosis ongallstone formation.
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Key Findings & Data:In this study, we investigated the contribution ofthyrotoxicosis to gallstone formation in rabbits.Methods: Forty-four New Zealand rabbits were used.
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Conclusion & Impact:Atthe end of seven weeks, all rabbits were sacrificed, blood was collectedfor analysis, and cholecystectomy was performed.Results: Serum levels of both free triiodothyronine (FT3) and thyroxine(FT4) were significantly higher in rabbits receiving thyroid hormone(p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The etiopathogenesis of gallstone formation is well known, butonly a few studies have investigated the effects of thyrotoxicosis ongallstone formation. In this study, we investigated the contribution ofthyrotoxicosis to gallstone formation in rabbits.Methods: Forty-four New Zealand rabbits were used. The rabbits weredivided into six groups, with each group receiving a different diet. Atthe end of seven weeks, all rabbits were sacrificed, blood was collectedfor analysis, and cholecystectomy was performed.Results: Serum levels of both free triiodothyronine (FT3) and thyroxine(FT4) were significantly higher in rabbits receiving thyroid hormone(p

Özet

Amaç: Safra taşı oluşumun etiyopatogenezi bilinmesine rağmen, tirotoksikozun safra taşı oluşumu üzerinde etkisini araştıran çok az sayıda çalışma bulunmaktadır. Bu çalışmada tavşanlarda tirotoksikozun safra taşı üzerine etkileri araştırılmıştır. Yöntemler: Kırk dört adet Yeni Zelanda tipi tavşan kullanıldı. Tavşanlar, altı gruba bölündü ve her grup farklı diyetle beslendi. Çalışmanın 7. haftasında tavşanlar sakrifiye edilerek kan örnekleri alındı ve kolesistektomi yapıldı. Bulgular: Tiroksin hormonu verilen tavşanlarda serbest T3 ve T4 düzeyleri anlamlı şekilde yüksek bulundu (p

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Cite This Article

KAMA, N. A., GÜNAY, Y., BİLGİHAN, A., TÜTÜNCÜ, T., KORKMAZ, G., ÖCALAN, T. (2022). Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni, Cilt: 57 - Sayı: 1, 91–97. https://ajindex.com/articles/535089

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References (15)

  1. Acalovschi M. Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol 2014;20:7277-85.
  2. Wilkins T, Agabin E, Varghese J, Talukder A. Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. Prim Care 2017;44:575-97.
  3. Krawczyk M, Stokes CS, Lammert F. Genetics and treatment of bile duct stones: new approaches. Curr Opin Gastroenterol 2013;29:329-35.
  4. Koivusalo AI, Pakarinen MP, Sittiwet C, et al. Cholesterol, noncholesterol sterols and bile acids in paediatric gallstones. Dig Liver Dis 2010;42:61-6.
  5. Raghavendra CK, Srinivasan K. Influence of dietary tender cluster beans (Cyamopsis tetragonoloba) on biliary proteins, bile acid synthesis and cholesterol crystal growth in rat bile. Steroids 2015;94:21-30.
  6. Lambou-Gianoukos S, Heller SJ. Lithogenesis and bile metabolism. Surg Clin North Am 2008;88:1175-94.
  7. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver 2012;6:172-87.
  8. Xu G, Li Y, Jiang X, Chen H. CAV1 Prevents Gallbladder Cholesterol Crystallization by Regulating Biosynthesis and Transport of Bile Salts. J Cell Biochem 2016;117:2118-27.
  9. Pasternak A, Bugajska J, Szura M, et al. Biliary Polyunsaturated Fatty Acids and Telocytes in Gallstone Disease. Cell Transplant 2017;26:125-33.
  10. Lee EJ, Kim MH, Kim YR, Park JW, Park WJ. Proteasome inhibition protects against diet-induced gallstone formationthrough modulation of cholesterol and bile acid homeostasis. Int J Mol Med 2018;41:1715-23. Smelt AH. Triglycerides and gallstone formation. Clin Chim Acta 2010;411:1625-31.
  11. Wang Y, Yu X, Zhao QZ, et al. Thyroid dysfunction, either hyper or hypothyroidism, promotes gallstoneformation by different mechanisms. J Zhejiang Univ Sci B 2016;17:515-25.
  12. Bonde Y, Plosch T, Kuipers F, Angelin B, Rudling M. Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology 2012;56:1828-37.
  13. Pedrelli M, Pramfalk C, Parini P. Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport. World J Gastroenterol 2010;16:5958- 64. Ridker PM. From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection. Circ Res 2016;118:145-56.
  14. Di Ciaula A, Wang DQ, Portincasa P. An update on the pathogenesis of cholesterol gallstone disease. Curr Opin Gastroenterol 2017;34:71-80.
  15. Katsika D, G