Journals / Haseki Tıp Bülteni / 2019 / Cilt: 57 - Sayı: 3

The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats

Quercus coccifera L. Ekstresinin Random Patern Deri Flebi Nekrozu Üzerine Etkisi

Pages
249–254
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The percentage ofnecrosis was statistically significantly lower in group 3 than ingroups 1 and 2 (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Ischemia-reperfusion injury is an important cause of flaploss.
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Key Findings & Data:Random-pattern skinflaps, 9x3 cm in size, were applied on rats back and then therats were divided into three groups.
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Conclusion & Impact:The percentage ofnecrosis was statistically significantly lower in group 3 than ingroups 1 and 2 (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Ischemia-reperfusion injury is an important cause of flaploss. We investigated effects of Quercus coccifera L. extractknown to have anti-oxidant and anti-inflammatory activity onskin flap viability.Methods: Eighteen Wistar rats were used. Random-pattern skinflaps, 9x3 cm in size, were applied on rats back and then therats were divided into three groups. Following surgery, 2 cc ofnitrofurazone cream and 2 cc of Q. coccifera L. water extractwere applied daily in groups 2 and 3, respectively. Group 1received no treatment after surgery. The percentage of necrosison the flaps was calculated and histopathological examination ofthe tissue samples was made on day 7.Results: The mean percentage of necrosis was 44.7%, 42.5%and 21.8% group 1, 2 and 3, respectively. The percentage ofnecrosis was statistically significantly lower in group 3 than ingroups 1 and 2 (p

Özet

Amaç: İskemi-reperfüzyon hasarı önemli bir flep kaybı nedenidir. Bu çalışmada antioksidan ve antiinflamatuvar aktivitesi olduğu bilinen Quercus coccifera ekstresinin flep yaşayabilirliği üzerindeki etkisi incelenmiştir Yöntemler: On sekiz Wistar cinsi sıçan kullanıldı. Sıçanların sırt bölgesinde 9x3 cm’lik random patern deri flebi kaldırıldı ve daha sonra flep tekrar aynı yere iade edildi. Daha sonra ratlar üç gruba ayrıldı. Grup 2’deki sıçanların sırtlarına günde bir defa 2 cc nitrofurazon krem, grup 3’teki sıçanların sırtına ise günde bir defa 2 cc Q. coccifera ektresi uygulandı. Grup 1’deki sıçanlara flep cerrahisi dışında bir işlem yapılmadı. Flep cerrahisinden 7 gün sonra fleplerdeki nekroz miktarı hesaplandı ve doku örnekleri alınarak histopatolojik inceleme yapıldı Bulgular: Grup 1’de ortalama nekroz miktarı %44,1, grup 2’de %42,5 ve grup 3’de %21,8 olarak hesaplandı. Grup 3’deki nekroz miktarı, grup 1 ve grup 2’den istatistiksel olarak anlamlı olacak şekilde az olduğu tespit edildi (p

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Cite This Article

YÜZBAŞIOĞLU, M., BİLENSOY, E., UZ, A. K., ORHAN, E., AKA, İ. Ö., YAVUZ, B. (2022). The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats. Haseki Tıp Bülteni, Cilt: 57 - Sayı: 3, 249–254. https://ajindex.com/articles/535065

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