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Journals / Haseki Tıp Bülteni / 2019 / Cilt: 57 - Sayı: 4

Predictive Factors Affecting Axillary Lymph Node Metastasis in Breast Cancer

Meme Kanserinde Aksilla Metastazini Etkileyen Prediktif Faktörler

Cihad TATAR
Suat BENEK
Pages
356–361
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Aim: The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer.
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Key Findings & Data:The purpose of this study was to determine the factors that affect axillary lymph node involvement in breast cancer in addition to biological and pathological parameters to prevent unnecessary lymph node dissections.Methods: Immunohistochemical and pathologic features of 131 breast cancer patients, who underwent breast surgery, were investigated retrospectively.Results: ALNM was detected in 60% (n=79) of patients.
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Conclusion & Impact:In multivariate analysis, increased tumor size (T1; OR: 0.2, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer. Determination of breast cancer patients at risk for ALNM is important for treatment planning. The purpose of this study was to determine the factors that affect axillary lymph node involvement in breast cancer in addition to biological and pathological parameters to prevent unnecessary lymph node dissections.Methods: Immunohistochemical and pathologic features of 131 breast cancer patients, who underwent breast surgery, were investigated retrospectively.Results: ALNM was detected in 60% (n=79) of patients. In univariate analysis, histological grade, tumor size, lymphovascular invasion, perineural invasion, HER2 positivity and large intraductal component were found to be high risk factors for ALNM. In multivariate analysis, increased tumor size (T1; OR: 0.2, p

Özet

Amaç: Aksiller lenf nodülü metastazının (ALNM) tanı anındaki durumu, meme kanseri olan hastaların genel ve hastalıksız sağkalımı için en önemli prognostik faktörlerden biri olarak kabul edilmiştir. ALNM riski taşıyan meme kanseri hastalarının belirlenmesi, tedavi planı için önemlidir. Bu çalışmamızın amacı meme kanserinde aksiller lenf nodu tutulumunu etkileyen faktörleri gereksiz diseksiyon yapılan hasta grubunu belirlemek idi. Yöntemler: Meme kanseri nedeni ile cerrahi tedavi uygulanan 131 meme kanseri hastanın immünohistokimyasal ve patolojik özellikleri retrospektif olarak incelenerek kaydedildi. Bulgular: ALNM hastaların %60’ında (n=79) saptanmıştır. Univariate analizde histolojik grade, tümör boyutu, lenfovasküler invazyon, perinöral invazyon, HER2 pozitifliği ve geniş intraduktal bileşen ALNM için yüksek riskli bulundu. Multivariate analizde, artmış tümör boyutu (OR: 0,2, p

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Cite This Article

TATAR, C., BENEK, S. (2022). Predictive Factors Affecting Axillary Lymph Node Metastasis in Breast Cancer. Haseki Tıp Bülteni, Cilt: 57 - Sayı: 4, 356–361. https://ajindex.com/articles/535054

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