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Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 4

ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population

ACAN gen VNTR Polimorfizmi ve Türk Popülasyonundaki İntervertebral Disk Dejenerasyonu

Hasan Emre AYDIN
Serbülent YİĞİT
Osman DEMİR
Ayşe Feyda NURSAL
Tuba ÖZ
İsmail KAYA
Pages
309–314
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Allele 21 and 23 were more common in ones livingin rural areas (p=0.030) while allele 27 was the most frequent inones living in urban areas (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Intervertebral disc degeneration (IVDD) is caused byseveral genetic and environmental factors.
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Key Findings & Data:The disease group comprised 150 patients diagnosed withsymptomatic IVDD.
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Conclusion & Impact:Allele 21 and 23 were more common in ones livingin rural areas (p=0.030) while allele 27 was the most frequent inones living in urban areas (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Intervertebral disc degeneration (IVDD) is caused byseveral genetic and environmental factors. Aggrecan is themajor component of intervertebral disk matrix proteoglycanwith multiple functional domains. The aim of this study wasto investigate the possible association between ACAN (codingaggrecan) gene variable number tandem repeat (VNTR)polymorphism and susceptibility to IVDD.Methods: Two hundred and sixty subjects participated in thisstudy. The disease group comprised 150 patients diagnosed withsymptomatic IVDD. The control group consisted of 110 healthysubjects. The ACAN gene VNTR region was analyzed using thepolymerase chain reaction (PCR) method.Results: The most common allele in the patient and the controlgroup was 27 repeat allele (49% and 34.55%, respectively).Allele 26 was more frequent in males compared to females(p=0.030). Allele 21 and 23 were more common in ones livingin rural areas (p=0.030) while allele 27 was the most frequent inones living in urban areas (p

Özet

Amaç: İntervertebral disk dejenerasyonu (İVDD) çeşitli genetik ve çevresel faktörlerden kaynaklanır. Agrekan intervertebral disk matrisi proteoglikanın çoklu fonksiyonel etki alanlarına sahip ana bileşenidir. Bu çalışmanın amacı ACAN (agrekan kodlayan) gen değişken sayılı ardışık tekrar (VNTR) polimorfizmi ve İVDD yatkınlığı arasındaki olası ilişkiyi araştırmaktır. Yöntemler: ACAN VNTR polimorfizmi ve İVDD arasındaki ilişkiyi incelemek için, 260 kişi bu çalışmaya katıldı. Hasta grubu semptomatik İVDD tanısı alan 150 hastadan oluşmuştu. Kontrol grubu 110 sağlıklı kişiden oluşmuştu. ACAN geni VNTR polimorfizmi polimeraz zincir reaksiyonu (PZR) yöntemi ile analiz edildi. Bulgular: Hasta ve kontrol grubunda en sık görülen alel 27 tekrarlı aleldi (sırasıyla, %49 ve %34,55). Alel 26 erkeklerde kadınlara göre daha sıktı (p=0,030). Alel 27 en fazla şehirde yaşayanlarda bulunurken (p

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Cite This Article

AYDIN, H. E., YİĞİT, S., DEMİR, O., NURSAL, A. F., ÖZ, T., KAYA, İ. (2022). ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 4, 309–314. https://ajindex.com/articles/535041

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References (14)

  1. Kadow T, Sowa G, Vo N, Kang JD. Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? Clin Orthop Relat Res 2015;473:1903-12
  2. Vialle LR, Vialle EN, Henao JES, Giraldo G. Lumbar disc herniation. Rev Bras Ortop 2015;45:17-22
  3. Paz Aparicio J, Fernández Bances I, López-Anglada Fernández E, et al. The IL-1b (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation. Eur Spine J 2011;20:383-9
  4. Videman T, Saarela J, Kaprio J, et al. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum 2009;60:470-81
  5. Roughley PJ, Alini M, Antoniou J. The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. Biochem Soc Trans 2002;30:869-74
  6. Urban JPG, Roberts S, Ralphs JR. The nucleus of the intervertebral disc from development to degeneration. Amer Zool 2000;40:53-61
  7. Kawaguchi Y, Osada R, Kanamori M, et al. Association between an aggrecan gene polymorphism and lumbar disc degeneration. Spine 1999;24:2456-60
  8. Doege KJ, Coulter SN, Meek LM, Maslen K, Wood JG. A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population. J Biol Chem 1997;272:13974-9
  9. Cong L, Pang H, Xuan D, Tu GJ. Association between the expression of aggrecan and the distribution of aggrecan gene variable number of tandem repeats with symptomatic lumbar disc herniation in Chinese Han of Northern China. Spine 2010;35:1371-6
  10. Eser O, Eser B, Cosar M, et al. Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients. Genet Mol Res 2011;10:1923-30
  11. Eser B, Cora T, Eser O, et al. Association of the polymorphisms of vitamin D receptor and aggrecan genes with degenerative disc disease. Genet Test Mol Biomarkers 2010;14:313-7
  12. Solovieva S, Noponen N, Männikkö M, et al. Association between the aggrecan gene variable number of tandem repeats polymorphism and intervertebral disc degeneration. Spine (Phila Pa 1976) 2007;32:1700-5
  13. Casa NLL, Casa Junior AJ, Melo AV, et al. CASE-REPORT Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study. Genet Mol Res 2016:15
  14. Sambrook PN, MacGregor AJ, Spector TD. Genetic influences on cervical and lumbar dis