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Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 5

The Effect of Autosomal Dominant Polycystic Kidney Disease on Spirometric Parameters

Spirometrik Parametrelere Otozomal Dominant Polisitik Böbrek Hastalığının Etkisi

Gülfidan ÇAKMAK
Meltem GÜRSU
Abdullah ŞUMNU
Savaş ÖZTÜRK
Egemen CEBECİ
Tuba Elif ÖZLER
Zeynep KARAALİ
Faruk KARANDERE
Barış DÖNER
Mustafa SARI
Pages
447–451
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is thought that the difference may be statisticallysignificant when the study is performed with kidney volumeanalysis and larger patient population

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: There is no enough data on pulmonary involvement inautosomal dominant polycystic kidney disease (ADPKD).
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Key Findings & Data:Theaim of this study is to examine pulmonary function test inpatients with ADPKD with varying stages of renal function andto compare them with those in healthy controls.Methods: Forty-six patients with ADPKD and 43 healthy controlsubjects were included in the study.
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Conclusion & Impact:It is thought that the difference may be statisticallysignificant when the study is performed with kidney volumeanalysis and larger patient population
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: There is no enough data on pulmonary involvement inautosomal dominant polycystic kidney disease (ADPKD). Theaim of this study is to examine pulmonary function test inpatients with ADPKD with varying stages of renal function andto compare them with those in healthy controls.Methods: Forty-six patients with ADPKD and 43 healthy controlsubjects were included in the study. Pulmonary function test wasperformed for each patient after routine physical examinationand biochemical analysis.Results: Age, gender, weight, height and smoking rate weresimilar in both groups. Seven patients (15.2%) had restrictivepattern and one (2.1%) had obstructive pattern in ADPKD groupwhile one patient (2.3%) had obstructive pattern and two (4.6%)had restrictive pattern in the control group. The frequency ofrestrictive pattern was not significantly higher (p=0.15), butforced vital capacity volume was significantly lower in the patientgroup (p=0.04).Conclusion: Restrictive spirometric pattern was more prevalentin the patient group, but there was no statistically significantdifference. It is thought that the difference may be statisticallysignificant when the study is performed with kidney volumeanalysis and larger patient population

Özet

Amaç: Otozomal dominant polikistik böbrek hastalığında (ODPBH) akciğer tutulumu için literatürde yeterli veri yoktur. Bu çalışmanın amacı, ODPBH’nin ve farklı evrelerinini, solunum fonksiyon testleri üzerine etkisini incelemektir. Yöntemler: Kırk altı ODPBH hastası ve 43 sağlıklı kontrol olgusu çalışmaya dahil edildi. Her olgu için rutin fizik muayene ve biyokimyasal analizden sonra solunum fonksiyon testleri yapıldı. Bulgular: Yaş, cinsiyet, kilo, boy ve sigara içme oranı her iki grupta benzerdi. Otozomal dominant polikistik böbrek hastalığı grubunda yedi hastada (%15,2) restriktif patern, bir hastada (%2,1) obstrüktif patern, kontrol grubunda bir hastada (%2,3) obstrüktif patern, iki hastada (%4,6) restriktif patern tespit edildi. Restriktif patern, iki grupta benzer olmakla birlikte (p=0,15), zorlu vital kapasite hacmi hasta grubunda anlamlı olarak düşüktü (p=0,04). Sonuç: Hasta grubunda restriktif spirometrik patern daha sık görüldü, ancak istatistiksel olarak anlamlı bir fark yoktu. Çalışma böbrek hacim analizi ve daha büyük hasta popülasyonu ile yapıldığında, farkın istatistiksel olarak anlamlı olabileceği düşünülmektedir.

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Cite This Article

ÇAKMAK, G., GÜRSU, M., ŞUMNU, A., ÖZTÜRK, S., CEBECİ, E., ÖZLER, T. E., KARAALİ, Z., KARANDERE, F., DÖNER, B., SARI, M. (2022). The Effect of Autosomal Dominant Polycystic Kidney Disease on Spirometric Parameters. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 5, 447–451. https://ajindex.com/articles/535032

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