Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 1

Does Microvascular Function Play a Role in the Etiology of Bell’s Palsy?

Bell’s Palsi Gelişimi ve Prognozununda Mikrovasküler Fonksiyonun Rolü Var mıdır?

Pages
99–104
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It has been thought that the CD and PORH values were normal in the BP patients and that a microvascular mechanism was not a possible factor for the development and prognosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of our study was to investigate whether systemic microvascular function affects the development and prognosis of Bell’s palsy (BP) or not.Methods: Sixty patients, who were admitted to our hospital between June 2017 and May 2018 and diagnosed with BP, were included as the BP group, and 60 healthy volunteers who came to the hospital for health screening, were included as the control group in our study.
📊
Key Findings & Data:The BP group was examined 3 months after the treatment and were divided into two groups according to the House-Brackmann Grading system.
💡
Conclusion & Impact:It has been thought that the CD and PORH values were normal in the BP patients and that a microvascular mechanism was not a possible factor for the development and prognosis.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of our study was to investigate whether systemic microvascular function affects the development and prognosis of Bell’s palsy (BP) or not.Methods: Sixty patients, who were admitted to our hospital between June 2017 and May 2018 and diagnosed with BP, were included as the BP group, and 60 healthy volunteers who came to the hospital for health screening, were included as the control group in our study. The BP group was examined 3 months after the treatment and were divided into two groups according to the House-Brackmann Grading system. Capillary density (CD) and post-occlusive reactive hyperemia (PORH) values were measured by performing videocapillaroscopic examination through the nail fold for microvascular function, and statistical analysis was carried out among the groups.Results: The video-capillary results revealed that there was no significant difference in CD and PORH values (p>0.05). In the complete recovery and incomplete recovery group, the CD and PORH values were not significantly different (p>0.05).Conclusion: To the best of our knowledge, our study is the first study conducted in the literature. Even though the role of specific mechanisms in BP has not been fully understood, there was no significant difference between the BP patients and the healthy subjects and between the recovery and incomplete recovery groups with the capillaroscopic examination. It has been thought that the CD and PORH values were normal in the BP patients and that a microvascular mechanism was not a possible factor for the development and prognosis.

Özet

Amaç: Çalışmamızın amacı sistemik mikrovasküler fonksiyonun Bell’s palsi (BP) gelişimini ve prognozunu etkileyip etkilemediğini araştırmaktır. Yöntemler: Çalışmaya Haziran 2017 ve Mayıs 2018 tarihleri arasında hastanemize başvuran BP tanısı almış 60 hasta BP grubu olarak ve sağlık taraması için hastaneye gelen 60 sağlıklı gönüllü kontrol grubu olarak dahil edildi. BP grubu tedaviden 3 ay sonra muayene edilerek House-Brackmann derecelendirme sistemine göre iki gruba ayrıldı. Mikrovasküler fonksiyon için tırnak yatağından video-kapilleroskopik inceleme yapılarak kapiller dansite (CD) ve post-okluzif reaktif hiperemi (PORH) değerleri ölçüldü ve gruplar arasında istatistiksel analiz yapıldı. Bulgular: Video-kapilleroskopik sonuçlarda CD ve PORH değeri anlamlı (p>0,05) farklılık göstermemiştir. Tam iyileşme ve tam iyileşme olmayan gruplarında ortalama CD ve PORH değeri anlamlı (p>0,05) farklılık göstermemiştir. Sonuç: Çalışmamız bildiğimiz kadarıyla literatürde yapılan ilk çalışmadır. BP’de spesifik mekanizmaların rolü tam anlaşılmamasına rağmen kapilleroskopik inceleme ile BP hastaları ile sağlıklı kişiler arasında ve iyileşen, iyileşmeyen gruplar arasında anlamlı farklılık saptanmamıştır. BP hastalarında CD ve PORH değerlerinin normal olduğunu ve mikrovasküler bir mekanizmanın gelişim ve prognoz üzerine muhtemel bir faktör olmadığı düşünülmüştür.

🔖

Cite This Article

KOÇ, A. K., KOÇAK, H. E., ERDOĞAN, B. Ç., ULUSOY, H. A., ACIPAYAM, H., YİĞİTBAY, M., KAYA, K. H. (2022). Does Microvascular Function Play a Role in the Etiology of Bell’s Palsy?. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 1, 99–104. https://ajindex.com/articles/535012

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl 2002;122:4-30.
  2. Kefalidis G, Riga M, Argyropoulou P, et al. Is the width of the labyrinthine portion of the fallopian tube implicated in the pathophysiology of Bell’s palsy: a prospective clinical study using computed tomography. Laryngoscope 2010;120:1203-7.
  3. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanag- ihara N. Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med 1996;124:27-30.
  4. Bibas T, Jiang D, Gleeson J. Disorders of the facial nerve. In: Gleeson M, ed. Scott-Brown’s Otorhinolaryngology Head and Neck Surgery. 7th ed. London, England: Edward Arnold Ltd, 2008:3883-6.
  5. Proctor B, Nager GT. The facial canal: Normal anatomy, variations and anomalies. Ann Otol Rhinol Laryngol 1982;97:33-61. Francis HW. Anatomy of the temporal bone, external ear, and middle ear. Cummings Otolaryngology-Head and Neck Surgery 6th Edition, Saunders, 2015, 1977-86.
  6. Rizzoni D, Aalkjaer C, De Ciuceis C, et al. How to assess microvascular structure in humans. High Blood Press Cardiovasc 2011;18:169-77.
  7. Roustit, M, Cracowski JL. Assessment of endothelial and neurovascular function in human skin microcirculation. Trends Pharmacol Sci 2013;34:373-84.
  8. Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol 2018;105:370-2. Shore AC. Capillaroscopy and the measurement of capillary pressure. Br J Clin Pharmacol 2000;50:501-13.
  9. Tibirica E, Souza EG, De Lorenzo A, Oliveira GM. Reduced systemic microvascular density and reactivity in individuals with early onset coronary artery disease. Microvasc Res 2015;97:105-8.
  10. House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg 1985;93:146-7.
  11. Jeong JH, Sugii Y, Minamiyama M, Okamoto K. Measurement of RBC deformation and velocity in capillaries in vivo. Microvasc Res 2006;71:212-7. Strauer BE. Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure. Am J Cardiol 1990;65:34-41.
  12. Strain WD, Chaturvedi N, Hughes A, et al. Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens 2010;28:952-8.
  13. De Boer MP, Meijer RI, Wijnstok NJ, et al. Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity-asso