Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 4

Comparison of the Frequency and Severity of Depression Between Patients with Stage 4 and 5 Chronic Kidney Disease with and Without Kidney Transplantation

Böbrek Nakli Olmuş ve Olmamış Evre 4 ve 5 Kronik Böbrek Hastalığı Olan Olgularda Depresyon Sıklığı ve Şiddetinin Karşılaştırılması

Pages
376–381
Publication Date
2022-10-17
DOI
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In multivariate linear regression analysis, depressionscores were independently associated with parathormone [Exp(B): 0.997 (confidence interval (CI): 0.995-1.0); p=0.023] andferritin [Exp (B): 0.996 (CI: 0.994-0.998); p=0.01].Conclusion: Higher prevalence of depression in patients withCKD who received renal transplantation is a significant finding.Routine psychiatric evaluation should become a part of follow-upand treatment in both groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Patients with chronic kidney disease (CKD) are at anincreased risk for depression.
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Key Findings & Data:In the present study, we aimedto compare the frequency and severity of depression and its’association with demographical and laboratory parametersbetween stage 4 and 5 CKD patients with and without kidneytransplantation.Methods: The study included stage 4 and stage 5 CKD patientsnot on dialysis.
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Conclusion & Impact:In multivariate linear regression analysis, depressionscores were independently associated with parathormone [Exp(B): 0.997 (confidence interval (CI): 0.995-1.0); p=0.023] andferritin [Exp (B): 0.996 (CI: 0.994-0.998); p=0.01].Conclusion: Higher prevalence of depression in patients withCKD who received renal transplantation is a significant finding.Routine psychiatric evaluation should become a part of follow-upand treatment in both groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Patients with chronic kidney disease (CKD) are at anincreased risk for depression. In the present study, we aimedto compare the frequency and severity of depression and its’association with demographical and laboratory parametersbetween stage 4 and 5 CKD patients with and without kidneytransplantation.Methods: The study included stage 4 and stage 5 CKD patientsnot on dialysis. The patients were separated into two groups.Group 1 was composed of patients with renal transplantationand group 2 was composed of patients without renaltransplantation. The prevalence of depression was evaluatedusing the Beck Depression Inventory.Results: Forty-nine patients were in group 1 and 52 patients ingroup 2. The mean depression score in group 1 was statisticallysignificantly higher than in group 2 (16±15 vs 13.5±10;p=0.031). We found that depression score was correlatedwith parathormone levels (p=0.023) and serum ferritin levels(p=0.019). In multivariate linear regression analysis, depressionscores were independently associated with parathormone [Exp(B): 0.997 (confidence interval (CI): 0.995-1.0); p=0.023] andferritin [Exp (B): 0.996 (CI: 0.994-0.998); p=0.01].Conclusion: Higher prevalence of depression in patients withCKD who received renal transplantation is a significant finding.Routine psychiatric evaluation should become a part of follow-upand treatment in both groups.

Özet

Amaç: Kronik böbrek hastalarında (KBH) depresyon riski artmıştır. Bu çalışmamızda böbrek nakli olmuş ve olmamış evre 4 ve evre 5 kronik böbrek hastalığı olan olgularda depresyon sıklığı ve şiddetinin karşılaştırılmasını amaçladık. Yöntemler: Çalışmaya evre 4 ve evre 5 kronik böbrek hastalığı olup diyalize girmeyen hastalar dahil edildi. Hastalar, daha önce böbrek nakli olanlar grup 1; olmamış olanlar ise grup 2 olacak şekilde iki gruba ayrıldı. Hastaların depresyon sıklıklarının değerlendirilmesi amacıyla Beck Depresyon Envanteri kullanıldı. Bulgular: Grup 1 49, grup 2 ise 52 hastadan oluşmaktaydı. Depresyon skorları açısından, grup 1’de daha yüksek olmak üzere iki grup arasında istatistiksel olarak anlamlı farklılık tespit edildi (16±15 vs 13,5±10; p=0,031). Depresyon skorları ile parathormon (p=0,023) ve ferritin seviyeleri (p=0,019) arasında korelasyon tespit edildi. Çoklu lineer regresyon analizinde depresyon skorlarının parathormon [Exp (B): 0,997 güven aralığı (GA): 0,995-1,0); p=0,023] ve ferritin düzeyleri ile [Exp (B): 0,996 (GA: 0,994-0,998); p=0,01] bağımsız ilişkili olduğu tespit edildi. Sonuç: Böbrek nakli olmuş KBH’lerdeki daha yüksek depresyon sıklığı önemli bir bulgudur. Rutin psikiyatrik değerlendirme, her iki hasta grubunda takip ve tedavinin bir parçası olmalıdır.

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Cite This Article

BOZACI, İ., TATAR, E. (2022). Comparison of the Frequency and Severity of Depression Between Patients with Stage 4 and 5 Chronic Kidney Disease with and Without Kidney Transplantation. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 4, 376–381. https://ajindex.com/articles/535006

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