Journals / Haseki Tıp Bülteni / 2021 / Cilt: 59 - Sayı: 1

Effectiveness of Algan Hemostatic Agent in Bleeding Control: An Experimental Kidney Incision Model

Algan Hemostatik Ajanın Kanama Kontrolündeki Etkinliği: Deneysel Bir Böbrek İnsizyon Modeli

Pages
43–47
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The AHA has controlled the bleeding in the heparinized and non-heparinized groups 5±1.19 and 3±0.91 seconds respectively (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The purpose of this study is to evaluate the hemostatic efficacy of a novel plant originated blood stopper which is called Algan Hemostatic Agent (AHA) in uncontrolled kidney incision bleeding model.Methods: The study was conducted with thirty-two rats 5-7 weeks old.
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Key Findings & Data:The rats were randomly divided into 4 groups, each consisting of eight rats (Group 1: heparinized saline, 2: heparinized AHA, 3: non-heparinized saline, 4: non-heparinized AHA).
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Conclusion & Impact:The AHA has controlled the bleeding in the heparinized and non-heparinized groups 5±1.19 and 3±0.91 seconds respectively (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The purpose of this study is to evaluate the hemostatic efficacy of a novel plant originated blood stopper which is called Algan Hemostatic Agent (AHA) in uncontrolled kidney incision bleeding model.Methods: The study was conducted with thirty-two rats 5-7 weeks old. The rats were randomly divided into 4 groups, each consisting of eight rats (Group 1: heparinized saline, 2: heparinized AHA, 3: non-heparinized saline, 4: non-heparinized AHA). Experimental kidney incision was made, and saline soaked sponge was applied to the control group and AHA to the study group. Results: The duration of bleeding was significantly shorter in the AHA group compared to the control group. The AHA has controlled the bleeding in the heparinized and non-heparinized groups 5±1.19 and 3±0.91 seconds respectively (p

Özet

Amaç: Çalışmanın amacı Algan kanama durdurucu ajanın böbrek insizyon rat modelinde etkinliğini araştırmaktır. Yöntemler: Çalışma 5-7 haftalık otuz iki sıçan ile yapıldı. Sıçanlar rastgele her biri sekiz sıçandan oluşan 4 gruba ayrıldı (Grup 1: heparinize salin, 2: heparinize AHA, 3: non-heparinize salin, 4: non-heparinize AHA). Deneysel böbrek insizyonu yapıldı ve kontrol grubuna salin emdirilmiş spanç, çalışma grubuna AHA uygulandı. Bulgular: AHA grubunda kanama süresi kontrol grubuna göre anlamlı olarak daha kısaydı. AHA, heparinize ve heparinize olmayan gruplarda kanamayı sırasıyla 5±1,19 ve 3±0,91 saniyede kontrol etmiştir. Kontrol grubunda heparinize ve heparinize olmayan grupta kanama sırasıyla 180,6±25,4 ve 125,4±21 saniyede kontrol edildi. Sonuç: Bu çalışma, AHA’nın sıçan parsiyel nefrektomi modelinde kanamayı kontrol etmede faydalı olduğunu göstermiştir.

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Cite This Article

KUMANDAŞ, A., MİDİ, A., EKİCİ, H., KILIÇ, Y., ÖZGÖÇMEN, R. (2022). Effectiveness of Algan Hemostatic Agent in Bleeding Control: An Experimental Kidney Incision Model. Haseki Tıp Bülteni, Cilt: 59 - Sayı: 1, 43–47. https://ajindex.com/articles/534971

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