Journals / Harran Üniversitesi Veteriner Fakültesi Dergisi / 2018 / Cilt: 7 - Sayı: Özel Sayı

Effects of Xylazine-Ketamine, Xylazine-Propofoland Xylazine-Ketamine-Propofol Administrationon Some Physiological Parametersin Sheeps

Koyunlarda Ksilazin-Ketamin, Ksilazin-Propofol, Ksilazin-Ketamin-Propofol’ün Bazı Fizyolojik Parametreler Üzerine Etkileri

Pages
42–46
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was observed that the sheep well tolerated the alterations that occurred in their physiological parameters, as no disruption was detected in their vital functions.

📌 3 Key Takeaways

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Objective & Hypothesis:This study aimed at the investigation of the impact of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol combinations on certain physiological parameters in sheep.
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Key Findings & Data:The study was carried out on 28 one-year-old, clinically healthy, nulliparous Zom ewes, which weighed 43.27±4.76 kg.
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Conclusion & Impact:It was observed that the sheep well tolerated the alterations that occurred in their physiological parameters, as no disruption was detected in their vital functions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Propofol · Ketamin · Ksilazin

Abstract

This study aimed at the investigation of the impact of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol combinations on certain physiological parameters in sheep. The study was carried out on 28 one-year-old, clinically healthy, nulliparous Zom ewes, which weighed 43.27±4.76 kg. The animals were randomly assigned in equal numbers (n=7) to four groups, one of which was maintained for control purposes. Excluding the control group, Group 1 was given xylazine-ketamine (0.1 mg/kg-2.2 mg/kg), Group 2 was administered with xylazine-propofol (0.1 mg/kg-3 mg/kg) and Group 3 received xylazine-ketamine-propofol (0.1 mg/kg-2.2 mg/kg-3 mg/kg) by intravenous route. Physiological parameters were measured in all animals before the administration of the anaesthetic agents (at minute 0), and 5, 10, 15, 30, 45, 60 and 120 min after the administration of the anesthetics. The comparison of the three treatment groups with the control group for the physiological parameters measured demonstrated that the differences detected in heart rate at 120 min in Group 3, in respiratory rate at 5 and 30 min in Groups 1 and 3, in body temperature at 10, 15, 30 and 120 min in Group 2 and at 120 min in Group 3 were statistically significant. It was observed that the sheep well tolerated the alterations that occurred in their physiological parameters, as no disruption was detected in their vital functions.

Özet

Çalışmada, koyunlarda ksilazin-ketamin, ksilazin-propofol ve ksilazin- ketamin-propofol kombinasyonlarının bazı fizyolojik parametreler üzerine etkilerinin araştırılması amaçlandı. Çalışma ortalama canlı ağırlığı 43.27±4.76 kg olan 1 yaşlarında doğum yapmamış klinik olarak sağlıklı 28 adet Zom ırkı dişi koyun üzerinde yürütüldü. Hayvanlar eşit sayıda (n=7) ve rastgele biri kontrol olmak üzere dört gruba ayrıldı. Kontrol grubu dışında Grup 1’de bulunan hayvanlara ksilazin-ketamin (0.1 mg/kg-2.2 mg/kg), Grup 2’de bulunan hayvanlara ksilazin-propofol (0.1 mg/kg-3 mg/kg) ve Grup 3’te bulunan hayvanlara ksilazin-ketamin-propofol (0.1 mg/kg-2.2 mg /kg-3 mg/kg) kombinasyonları intravenöz olarak uygulandı. Tüm hayvanlardan anestetik ajanların uygulanmasından önce (0.dakika) ve anestetiklerin uygulanmasından sonra 5.,10., 15., 30., 45., 60. ve 120. dk’larda fizyolojik parametre ölçümleri yapıldı. Fizyolojik parametreler bakımından, her üç grup kontrol grubu ile kıyaslandığında kalp atım sayısında sadece Grup 3’te 120. dk’da, solunum sayısında Grup 1 ve Grup 3’te 5. dk ile 30. dk’da, vücut ısısında Grup 2’de 10., 15., 30. ve 120. dk’larda, Grup 3’te ise sadece 120. dk’da meydana gelen fark önemli idi. Koyunların, fizyolojik parametrelerde meydana gelen değişiklikleri vital fonksiyonlarda herhangi bir bozulma göstermeksizin iyi derecede tolere ettikleri izlendi.

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Cite This Article

GÖKALP, E., ALTAN, S., GÜRGÖZE, S. (2022). Effects of Xylazine-Ketamine, Xylazine-Propofoland Xylazine-Ketamine-Propofol Administrationon Some Physiological Parametersin Sheeps. Harran Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 7 - Sayı: Özel Sayı, 42–46. https://ajindex.com/articles/534298

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